Date published: 2025-12-15

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cis-(Z)-Flupenthixol dihydrochloride (CAS 51529-01-2)

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Alternate Names:
cis-(Z)-Flupentixol Dihydrochloride; 4-[3-[(3Z)-2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol Hydrochloride
Application:
cis-(Z)-Flupenthixol dihydrochloride is A dopamine receptor antagonist
CAS Number:
51529-01-2
Molecular Weight:
507.44
Molecular Formula:
C23H25F3N2OS•2HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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cis-(Z)-Flupenthixol dihydrochloride is a compound of significant interest in neuropsychopharmacological research. This compound′s configuration allows scientists to delve into the stereospecific mechanisms of action on neurotransmitter receptors, particularly dopamine receptors, and their influence on synaptic transmission. The dihydrochloride salt form provides increased solubility for use in various experimental setups, including cell culture studies. In the field of chemical synthesis, the stereochemistry of cis-(Z)-Flupenthixol dihydrochloride is studied to refine stereoselective synthetic pathways, which are pertinent for the production of enantiomerically pure compounds. Moreover, its stable dihydrochloride structure is leveraged in spectroscopic studies, including NMR and crystallography, to gain insights into the molecular conformation and intermolecular interactions of similar compounds.


cis-(Z)-Flupenthixol dihydrochloride (CAS 51529-01-2) References

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  5. Intrathecal chlorprothixene, cis(z)-flupenthixol, chlorpromazine and fluphenazine for prolonged spinal blockades of sensory and motor functions in rats.  |  Chen, YW., et al. 2012. Eur J Pharmacol. 693: 31-6. PMID: 22926199
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  7. Discovery of antagonists of tick dopamine receptors via chemical library screening and comparative pharmacological analyses.  |  Ejendal, KF., et al. 2012. Insect Biochem Mol Biol. 42: 846-53. PMID: 23213654
  8. Effect of cis-(Z)-flupentixol on DPPC membranes in the presence and absence of cholesterol.  |  Yonar, D. and Sunnetcioglu, MM. 2016. Chem Phys Lipids. 198: 61-71. PMID: 27282777
  9. Drugs which stimulate or facilitate central GABAergic transmission interact synergistically with delta-9-tetrahydrocannabinol to produce marked catalepsy in mice.  |  Pertwee, RG., et al. 1988. Neuropharmacology. 27: 1265-70. PMID: 2854226
  10. The hypothermic response of mice to delta-9-tetrahydrocannabinol is enhanced by chlorpromazine, thioxanthenes, alpha-adrenoceptor antagonists and pentolinium but not by SCH 23390 or sulpiride.  |  Pertwee, RG., et al. 1988. Neuropharmacology. 27: 149-55. PMID: 2895430
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

cis-(Z)-Flupenthixol dihydrochloride, 10 mg

sc-394276A
10 mg
$273.00

cis-(Z)-Flupenthixol dihydrochloride, 50 mg

sc-394276B
50 mg
$502.00

cis-(Z)-Flupenthixol dihydrochloride, 100 mg

sc-394276
100 mg
$686.00