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cis-Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and antiinflammatory activity. cis-Resveratrol is the double bond isomer of trans-resveratrol, the more often studied and naturally abundant of the two resveratrol isomers. cis-Resveratrol exhibits antioxidant activity in the μM range similar to that observed with trans-resveratrol. It blocks production of reactive oxygen species (ROS) by inhibition of NAD(P)H oxidase (Nox) and also inhibits production of nitric oxide. At a concentration of 100 μM, cis-resveratrol significantly inhibits the expression of genes related to the Rel/NF-κB/Ικβ family, adhesion molecules, and acute-phase proteins in LPS and INF-γ-stimulated murine peritoneal macrophages. cis-Resveratrol inhibits uptake of noradrenaline and 5-HT by synaptosomes from rat brain with IC50 values of 79 and 51 μM, respectively. It also inhibits human MOA-A (monoamine oxidase-A) and MOA-B with IC50 values of 25 and 61μM, respectively, which is similar to, but slightly less effective than, values obtained with trans-resveratrol. cis-Resveratrol is an inhibitor of Cox-1.
1 Rotondo, S., Rajtar, G., Manarini, S., et al. Effect of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function. Br J Pharmacol 123 1691-1699 (1998). 2 Orallo, F. Comparative studies of the antioxidant effects of cis- and trans-resveratrol. Current Medicinal Chemistry 13 87-98 (2006). 3 Leiro, J., Arranz, J.A., Fraiz, N., et al. Effect of cis-resveratrol on genes involved in nuclear factor kappa B signaling. International Immunopharmacology 5 393-406 (2005). 4 Yáñez, M., Fraiz, N., Cano, E., et al. Inhibitory effects of cis- and trans-resveratrol on noradrenaline and 5-hydroxytryptamine uptake and on monoamine oxidase activity. Biochem Biophys Res Commun 344 688-695 (2006).
See how others have used cis-Resveratrol Solution (in Ethanol). Click on the entry to view the PubMed entry .
PMID: # 22774205 2012. J. Biochem. 152: 331-40.
PMID: # 21438545 Stark, T. et al. 2011. Anal. Chem. 83: 3398-405.
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