cis-Resveratrol Solution (in Ethanol) (CAS 61434-67-1)

cis-Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and antiinflammatory activity. cis-Resveratrol is the double bond isomer of trans-resveratrol, the more often studied and naturally abundant of the two resveratrol isomers. cis-Resveratrol exhibits antioxidant activity in the μM range similar to that observed with trans-resveratrol. It blocks production of reactive oxygen species (ROS) by inhibition of NAD(P)H oxidase (Nox) and also inhibits production of nitric oxide. At a concentration of 100 μM, cis-resveratrol significantly inhibits the expression of genes related to the Rel/NF-κB/Ικβ family, adhesion molecules, and acute-phase proteins in LPS and INF-γ-stimulated murine peritoneal macrophages. cis-Resveratrol inhibits uptake of noradrenaline and 5-HT by synaptosomes from rat brain with IC₅₀ values of 79 and 51 μM, respectively. It also inhibits human MOA-A (monoamine oxidase-A) and MOA-B with IC₅₀ values of 25 and 61μM, respectively, which is similar to, but slightly less effective than, values obtained with trans-resveratrol. cis-Resveratrol is an inhibitor of Cox-1.