Date published: 2026-2-26

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cis-Permethrin (CAS 61949-76-6)

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CAS Number:
61949-76-6
Molecular Weight:
391.29
Molecular Formula:
C21H20Cl2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cis-Permethrin is a synthetic pyrethroid insecticide. It exerts high toxicity against insects. Pyrethroids like permethrin are chemically designed to mimic the insecticidal activity of pyrethrins, natural compounds extracted from the flowers of Chrysanthemum cinerariifolium. These synthetic variants often exhibit enhanced stability and prolonged effectiveness. The effectiveness of cis-permethrin, like other pyrethroids, lies in its neurotoxic action on insects. It acts by disturbing the function of sodium channels in nerve cells, leading to prolonged depolarization and preventing the nerve from returning to its resting state. The cis configuration of permethrin is particularly important because the bioactivity of pyrethroids can vary significantly between different isomeric forms. Generally, the cis isomers have been found to possess higher insecticidal activity and, consequently, are often preferred in formulations targeting a wide range of pests.


cis-Permethrin (CAS 61949-76-6) References

  1. Synergism between cis-permethrin and benzoyl phenyl urea insect growth regulators against Aedes aegypti larvae.  |  Sfara, V., et al. 2007. J Am Mosq Control Assoc. 23: 24-8. PMID: 17536364
  2. Permethrin may induce adult male mouse reproductive toxicity due to cis isomer not trans isomer.  |  Zhang, SY., et al. 2008. Toxicology. 248: 136-41. PMID: 18455858
  3. A pharmacokinetic model of cis- and trans-permethrin disposition in rats and humans with aggregate exposure application.  |  Tornero-Velez, R., et al. 2012. Toxicol Sci. 130: 33-47. PMID: 22859315
  4. Determination of cis-permethrin, trans-permethrin and associated metabolites in rat blood and organs by gas chromatography-ion trap mass spectrometry.  |  Lestremau, F., et al. 2014. Anal Bioanal Chem. 406: 3477-87. PMID: 24718437
  5. In vitro metabolism of cis- and trans-permethrin by rat liver microsomes, and its effect on estrogenic and anti-androgenic activities.  |  Tange, S., et al. 2014. Environ Toxicol Pharmacol. 37: 996-1005. PMID: 24731973
  6. PBPK modeling of the cis- and trans-permethrin isomers and their major urinary metabolites in rats.  |  Willemin, ME., et al. 2016. Toxicol Appl Pharmacol. 294: 65-77. PMID: 26802525
  7. Simultaneous determination of cis-permethrin and trans-permethrin in rat plasma and brain tissue using gas chromatography-negative chemical ionization mass spectrometry.  |  Hooshfar, S., et al. 2017. J Chromatogr B Analyt Technol Biomed Life Sci. 1060: 291-299. PMID: 28651172
  8. Bioanalytical methods for the quantification of cis-permethrin and trans-permethrin in biological samples.  |  Hooshfar, S. and Bartlett, MG. 2017. Bioanalysis. 9: 1433-1435. PMID: 29056073
  9. Age Dependency of Blood-Brain Barrier Penetration by cis- and trans-Permethrin in the Rat.  |  Mortuza, TB., et al. 2019. Drug Metab Dispos. 47: 234-237. PMID: 30523003
  10. Plasma Protein and Lipoprotein Binding of Cis- and Trans-Permethrin and Deltamethrin in Adult Humans and Rats.  |  Sethi, P., et al. 2019. Drug Metab Dispos. 47: 941-948. PMID: 31248885
  11. Determination of maternal and foetal distribution of cis- and trans-permethrin isomers and their metabolites in pregnant rats by liquid chromatography tandem mass spectrometry (LC-MS/MS).  |  Personne, S., et al. 2019. Anal Bioanal Chem. 411: 8043-8052. PMID: 31748895
  12. Kinetics of metabolism of deltamethrin and cis- and trans-permethrin in vitro. Studies using rat and human liver microsomes, isolated rat hepatocytes and rat liver cytosol.  |  Price, RJ., et al. 2021. Xenobiotica. 51: 40-50. PMID: 32757971
  13. Metabolism of trans- and cis-permethrin, trans- and cis-cypermethrin, and decamethrin by microsomal enzymes.  |  Shono, T., et al. 1979. J Agric Food Chem. 27: 316-25. PMID: 429687

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

cis-Permethrin, 50 mg

sc-257254
50 mg
$374.00