Date published: 2026-4-19

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cis,cis-Muconic acid (CAS 1119-72-8)

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Alternate Names:
cis,cis-2,4-Hexadienedioic acid
Application:
cis,cis-Muconic acid is a naturally-occurring organic acid
CAS Number:
1119-72-8
Purity:
≥97%
Molecular Weight:
142.11
Molecular Formula:
C6H6O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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cis,cis-Muconic acid (CCMA) is a naturally-occurring organic acid used as an important intermediate in the synthesis of a variety of compounds. For example, it is used in the manufacture of several widely-used consumer plastics and dyes. Its microbial production via extending shikimate pathway has been reported. In vitro studies have been conducted to investigate the effects of cis,cis-Muconic acid on cell proliferation, apoptosis, activities of enzymes involved in metabolic pathways, and the expression of certain genes. Antioxidant, anti-inflammatory, and anti-cancer properties have been found.


cis,cis-Muconic acid (CAS 1119-72-8) References

  1. Role of cis-cis muconic acid in the catalysis of Pseudomonas putida chlorocatechol 1,2-dioxygenase.  |  Melo, FA., et al. 2010. Int J Biol Macromol. 47: 233-7. PMID: 20452370
  2. Oxidative bioconversion of toluene to 1,3-butadiene-1,4-dicarboxylic acid (cis,cis-muconic acid).  |  Chua, JW. and Hsieh, JH. 1990. World J Microbiol Biotechnol. 6: 127-43. PMID: 24429984
  3. Metabolic engineering of Klebsiella pneumoniae for the production of cis,cis-muconic acid.  |  Jung, HM., et al. 2015. Appl Microbiol Biotechnol. 99: 5217-25. PMID: 25681152
  4. Engineering catechol 1, 2-dioxygenase by design for improving the performance of the cis, cis-muconic acid synthetic pathway in Escherichia coli.  |  Han, L., et al. 2015. Sci Rep. 5: 13435. PMID: 26306712
  5. [Construction and optimization of microbial cell factories for producing cis, cis-muconic acid].  |  Song, G., et al. 2016. Sheng Wu Gong Cheng Xue Bao. 32: 1212-1223. PMID: 29022322
  6. Characterization of a non-phosphotransferase system for cis,cis-muconic acid production in Corynebacterium glutamicum.  |  Shin, WS., et al. 2018. Biochem Biophys Res Commun. 499: 279-284. PMID: 29571737
  7. Biosynthesis of adipic acid via microaerobic hydrogenation of cis,cis-muconic acid by oxygen-sensitive enoate reductase.  |  Sun, J., et al. 2018. J Biotechnol. 280: 49-54. PMID: 29885337
  8. Metabolic engineering of Corynebacterium glutamicum for the production of cis, cis-muconic acid from lignin.  |  Becker, J., et al. 2018. Microb Cell Fact. 17: 115. PMID: 30029656
  9. Recent Advances in Microbial Production of cis,cis-Muconic Acid.  |  Choi, S., et al. 2020. Biomolecules. 10: PMID: 32854378
  10. Integrating continuous hypermutation with high-throughput screening for optimization of cis,cis-muconic acid production in yeast.  |  Jensen, ED., et al. 2021. Microb Biotechnol. 14: 2617-2626. PMID: 33645919
  11. An integrated yeast-based process for cis,cis-muconic acid production.  |  Wang, G., et al. 2022. Biotechnol Bioeng. 119: 376-387. PMID: 34786710
  12. Catechol 1,2-Dioxygenase From Paracoccus sp. MKU1-A Greener and Cleaner Bio-Machinery for cis, cis-Muconic Acid Production by Recombinant E. coli.  |  Aravind, MK., et al. 2021. Front Bioeng Biotechnol. 9: 703399. PMID: 34790650
  13. Systems metabolic engineering upgrades Corynebacterium glutamicum to high-efficiency cis, cis-muconic acid production from lignin-based aromatics.  |  Weiland, F., et al. 2023. Metab Eng. 75: 153-169. PMID: 36563956
  14. Inducible Synthetic Growth Regulation Using the ClpXP Proteasome Enhances cis,cis-Muconic Acid and Glycolic Acid Yields in Saccharomyces cerevisiae.  |  Kakko, N., et al. 2023. ACS Synth Biol. 12: 1021-1033. PMID: 36976676
  15. Correction to 'Whole-Cell Bioconversion of Renewable Biomasses-Related Aromatics to cis,cis-Muconic Acid'.  |  Molinari, F., et al. 2023. ACS Sustain Chem Eng. 11: 5802. PMID: 37067892

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

cis,cis-Muconic acid, 5 g

sc-223893
5 g
$198.00