Date published: 2026-4-20

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cis-4-Aminocyclohexanecarboxylic acid (CAS 3685-23-2)

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CAS Number:
3685-23-2
Molecular Weight:
143.18
Molecular Formula:
C7H13NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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cis-4-Aminocyclohexanecarboxylic acid is actively in chemical applications, particularly in the study of peptide synthesis and protein engineering. cis-4-Aminocyclohexanecarboxylic acid serves as a building block in the development of peptides that mimic proteins, which helps in understanding protein folding and stability. Its unique cyclic structure and chiral properties make cis-4-Aminocyclohexanecarboxylic acid an interesting subject in the creation of constrained peptides and peptidomimetics, aiming to enhance biological activity and stability. Some also investigate its incorporation into polymers to explore the effects on the physical and chemical properties of polymeric materials. Cis-4-Aminocyclohexanecarboxylic acid is in catalysis studies, where its role in asymmetric synthesis helps in producing optically active compounds.


cis-4-Aminocyclohexanecarboxylic acid (CAS 3685-23-2) References

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  2. A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease.  |  Zolotarevsky, Y., et al. 2002. Gastroenterology. 123: 163-72. PMID: 12105845
  3. Hydrogen-bonding patterns in cis-4-ammoniocyclohexanecarboxylate hemihydrate.  |  Avila, EE., et al. 2004. Acta Crystallogr C. 60: o759-61. PMID: 15467151
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  6. Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2).  |  Edwards, N., et al. 2011. Biochim Biophys Acta. 1808: 260-70. PMID: 20691150
  7. Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: use of a conformation-based hypothesis to facilitate compound design.  |  Walker, DP., et al. 2013. Bioorg Med Chem Lett. 23: 1120-6. PMID: 23298810
  8. Development of SPME method for concomitant sample preparation of rocuronium bromide and tranexamic acid in plasma.  |  Gorynski, K., et al. 2014. J Pharm Biomed Anal. 92: 183-92. PMID: 24525565
  9. (R-X-R)4 -Motif Peptides Containing Conformationally Constrained Cyclohexane-Derived Spacers: Effect on Cellular Uptake.  |  Bhosle, GS. and Fernandes, M. 2017. ChemMedChem. 12: 1743-1747. PMID: 28948715
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  11. Discovery of soluble epoxide hydrolase inhibitors through DNA-encoded library technology (ELT).  |  Ding, Y., et al. 2021. Bioorg Med Chem. 41: 116216. PMID: 34023664
  12. cis-4-[[[(2-Chloroethyl)nitrosoamino]carbonyl]methylamino] cyclohexanecarboxylic acid, a nitrosourea with latent activity against an experimental solid tumor.  |  Johnston, TP., et al. 1984. J Med Chem. 27: 97-9. PMID: 6690691
  13. Revealing the role of bifunctional molecules in crystallizing methylammonium lead iodide through geometric isomers  |  Zhang, W., Zhang, W., Wang, K., Chu, Y., Du, J., Mei, A.,.. & Han, H. 2021. Chemistry of Materials. 33(11): 4014-4022.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

cis-4-Aminocyclohexanecarboxylic acid, 1 g

sc-255026
1 g
$59.00