Molecular structure of cis-3,4′,5-Trimethoxy-3′-aminostilbene, CAS Number: 586410-12-0
cis-3,4′,5-Trimethoxy-3′-aminostilbene (CAS 586410-12-0)
Application:
cis-3,4′,5-Trimethoxy-3′-aminostilbene is a resveratrol derivative with apoptotic activity
CAS Number:
586410-12-0
Molecular Weight:
285.34
Molecular Formula:
C17H19NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A Resveratrol derivative which shows apoptotic activity at nanomolar concentrations. Has an IC50= 0.3. It showed activity toward resistant HL60R cells and their activity was higher than that of several classic chemotherapeutic agents.
cis-3,4′,5-Trimethoxy-3′-aminostilbene (CAS 586410-12-0) References
- Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents. | Roberti, M., et al. 2003. J Med Chem. 46: 3546-54. PMID: 12877593
- Suppression of human monocyte tissue factor induction by red wine phenolics and synthetic derivatives of resveratrol. | Kaur, G., et al. 2007. Thromb Res. 119: 247-56. PMID: 16507316
- Stilbene derivatives that are colchicine-site microtubule inhibitors have antileukemic activity and minimal systemic toxicity. | Cao, TM., et al. 2008. Am J Hematol. 83: 390-7. PMID: 18175355
- cis-3, 4', 5-Trimethoxy-3'-aminostilbene disrupts tumor vascular perfusion without damaging normal organ perfusion. | Durrant, D., et al. 2009. Cancer Chemother Pharmacol. 63: 191-200. PMID: 18365199
- Mechanism of cell death induced by cis-3, 4', 5-trimethoxy-3'-aminostilbene in ovarian cancer. | Durrant, D., et al. 2008. Gynecol Oncol. 110: 110-7. PMID: 18433847
- Development of water soluble derivatives of cis-3, 4', 5-trimethoxy-3'-aminostilbene for optimization and use in cancer therapy. | Durrant, DE., et al. 2009. Invest New Drugs. 27: 41-52. PMID: 18516499
- Novel A-ring and B-ring modified combretastatin A-4 (CA-4) analogues endowed with interesting cytotoxic activity. | Simoni, D., et al. 2008. J Med Chem. 51: 6211-5. PMID: 18783207
- Versatile synthesis of new cytotoxic agents structurally related to hemiasterlins. | Simoni, D., et al. 2010. Bioorg Med Chem Lett. 20: 3431-5. PMID: 20430617
- Stilbene 5c, a microtubule poison with vascular disrupting properties that induces multiple modes of growth arrest and cell death. | Alotaibi, MR., et al. 2013. Biochem Pharmacol. 86: 1688-98. PMID: 24144631
- A novel hybrid drug between two potent anti-tubulin agents as a potential prolonged anticancer approach. | Marchetti, P., et al. 2016. Eur J Pharm Sci. 91: 50-63. PMID: 27262542
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cis-3,4',5-Trimethoxy-3'-aminostilbene, 10 mg | sc-217910 | 10 mg | $300.00 |