Date published: 2026-4-26

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cis-1,2,3,6-Tetrahydrophthalimide (CAS 1469-48-3)

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Alternate Names:
cis-4-Cyclohexene-1,2-dicarboximide
CAS Number:
1469-48-3
Molecular Weight:
151.16
Molecular Formula:
C8H9NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cis-1,2,3,6-Tetrahydrophthalimide (THPI) is a cyclic organic compound belonging to the phthalimide family, characterized by four interconnected rings of carbon and nitrogen atoms. This versatile compound has found widespread use in diverse scientific research applications. One of its significant roles lies in acting as a ligand for the synthesis of metal complexes, a catalyst for polymer synthesis, and a reagent for various organic compound syntheses. Moreover, it has been extensively employed in biochemical studies, encompassing investigations into enzyme kinetics and cell signaling pathways. Additionally, in laboratory experiments, cis-1,2,3,6-Tetrahydrophthalimide has proven valuable for studying the effects of different compounds on cellular processes. Although the precise mechanism of action of cis-1,2,3,6-Tetrahydrophthalimide remains somewhat elusive, it is thought to serve as an inhibitor of drug-metabolizing enzymes and the enzyme cyclooxygenase-2 (COX-2). Furthermore, research has shown that this compound binds to specific proteins within cell membranes, suggesting potential involvement in regulating cellular processes. The compound cis-1,2,3,6-Tetrahydrophthalimide holds significant importance in the scientific community, offering a wide array of applications and promising insights into various biochemical phenomena, though further investigations are required to fully comprehend its intricate mechanisms of action.


cis-1,2,3,6-Tetrahydrophthalimide (CAS 1469-48-3) References

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  4. Liquid chromatography-tandem mass spectrometry (LC/APCI-MS/MS) methods for the quantification of captan and folpet phthalimide metabolites in human plasma and urine.  |  Berthet, A., et al. 2011. Anal Bioanal Chem. 399: 2243-55. PMID: 21229238
  5. Imidase catalyzing desymmetric imide hydrolysis forming optically active 3-substituted glutaric acid monoamides for the synthesis of gamma-aminobutyric acid (GABA) analogs.  |  Nojiri, M., et al. 2015. Appl Microbiol Biotechnol. 99: 9961-9. PMID: 26205522
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

cis-1,2,3,6-Tetrahydrophthalimide, 100 g

sc-257248
100 g
$32.00