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Cirazoline hydrochloride (CAS 40600-13-3)

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Alternate Names:
2-((2-Cyclopropylphenoxy)methyl)-4,5-dihydro-1H-imidazolium chloride
Application:
Cirazoline hydrochloride is a selective α1 agonist
CAS Number:
40600-13-3
Molecular Weight:
252.74
Molecular Formula:
C13H16N2O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cirazoline hydrochloride functions as an α1-adrenergic receptor agonist. It acts by binding to and activating α1-adrenergic receptors, leading to the stimulation of phospholipase C and the subsequent increase in intracellular calcium levels. Cirazoline hydrochloride may induce the release of norepinephrine from sympathetic nerve terminals. Cirazoline Hydrochloride′s mechanism of action involves its interaction with α1-adrenergic receptors on smooth muscle cells, leading to the activation of signaling pathways that ultimately result in vasoconstriction. In experimental applications, cirazoline hydrochloride is utilized to investigate the physiological and pharmacological effects of α1-adrenergic receptor activation, as well as to study the role of these receptors in various cellular and tissue functions.


Cirazoline hydrochloride (CAS 40600-13-3) References

  1. Influence of mitochondrial inhibition on global and local [Ca(2+)](I) in rat tail artery.  |  Swärd, K., et al. 2002. Circ Res. 90: 792-9. PMID: 11964372
  2. Cholesterol depletion disrupts caveolae and differentially impairs agonist-induced arterial contraction.  |  Dreja, K., et al. 2002. Arterioscler Thromb Vasc Biol. 22: 1267-72. PMID: 12171786
  3. Regulation of the release of serotonin in the dorsal raphe nucleus by alpha1 and alpha2 adrenoceptors.  |  Pudovkina, OL., et al. 2003. Synapse. 50: 77-82. PMID: 12872296
  4. Selectivity profile of the alpha 2-adrenoceptor antagonist efaroxan in relation to plasma glucose and insulin levels in the rat.  |  Berridge, TL., et al. 1992. Eur J Pharmacol. 213: 205-12. PMID: 1355733
  5. Determining orthogonal and similar chromatographic systems from the injection of mixtures in liquid chromatography-diode array detection and the interpretation of correlation coefficients color maps.  |  Van Gyseghem, E., et al. 2004. J Chromatogr A. 1026: 117-28. PMID: 14763739
  6. Chromatographic data for pharmacological classification of imidazol(in)e drugs.  |  Gami-Yilinkou, R. and Kaliszan, R. 1991. J Chromatogr. 550: 573-84. PMID: 1663505
  7. Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors.  |  Maupoil, V., et al. 2007. Br J Pharmacol. 150: 899-905. PMID: 17325650
  8. Evidence that some imidazoline derivatives inhibit peripherally the vasopressor sympathetic outflow in pithed rats.  |  Monroy-Ordoñez, EB., et al. 2008. Auton Neurosci. 143: 40-5. PMID: 18774761
  9. State-dependent interactions between excitatory neuromodulators in the neuronal control of breathing.  |  Doi, A. and Ramirez, JM. 2010. J Neurosci. 30: 8251-62. PMID: 20554877
  10. Failure of selective antagonists (CH-38083 and idazoxan) to distinguish between prejunctional and postjunctional alpha 2-adrenoreceptors.  |  Lonart, G., et al. 1989. J Auton Pharmacol. 9: 149-58. PMID: 2565902
  11. Quantitative structure-retention relationship of selected imidazoline derivatives on α1-acid glycoprotein column.  |  Filipic, S., et al. 2016. J Pharm Biomed Anal. 127: 101-11. PMID: 26968888
  12. Postsynaptic alpha adrenoceptors and attenuation of vascular sympathetic responses in SHRs by captopril and enalapril.  |  Richer, C., et al. 1983. Eur Heart J. 4 Suppl G: 55-60. PMID: 6319143
  13. The role of 5-HT1A autoreceptors and alpha1-adrenoceptors in the modulation of 5-HT release--III. Clozapine and the novel putative antipsychotic S 16924.  |  Bengtsson, HJ., et al. 1998. Neuropharmacology. 37: 349-56. PMID: 9681933

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cirazoline hydrochloride, 10 mg

sc-203550
10 mg
$196.00