Cirazoline hydrochloride CAS: 40600-13-3
MF: C13H16N2O•HCl
MW: 252.74
A selective α1 agonist.

Cirazoline hydrochloride (CAS 40600-13-3)

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Alternate Names: 2-((2-Cyclopropylphenoxy)methyl)-4,5-dihydro-1H-imidazolium chloride
Application: Cirazoline hydrochloride is a selective α1 agonist
CAS Number: 40600-13-3
Molecular Weight: 252.74
Molecular Formula: C13H16N2O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Cirazoline hydrochloride is a selective AR (α1-Adrenoceptor) agonist.


References

1. Gellai, M. and Ruffolo, R.R. Jr. 1987. J. Pharmacol. Exp. Ther. 250: 723-728.
2. Wikberg, J.E. and Uklen, S. 1990. J. Neurochem. 55: 192-203.
3. Le Rouzic, M., et al. 1995. Eur. J. Pharmacol. 278: 261-264.

Physical State :
Solid
Solubility :
Soluble in water (100 mM), and DMSO (100 mM).
Storage :
Store at room temperature
Melting Point :
184-185° C
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
Adrenergic receptor alpha-2: IC50 = 59 nM (rat); Adrenergic receptor alpha-1: IC50 = 890 nM (rat); Plasmodium falciparum : IC50 = 12.59 µM
Ki Data :
α2A-AR: Ki= 58.88 nM (human); Nischarin: Ki= 99 nM (human); α2B-AR: Ki= 524.81 nM (human); α2C-AR: Ki= 549.54 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11957512
MDL Number :
MFCD00274034
EC Number :
254-995-3
SMILES :
C1CC1C2=CC=CC=C2OCC3=NCCN3.Cl

Download SDS (MSDS)

Certificate of Analysis

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What is Cyrazoline mostly used for? Please describe. Thanks

Asked by: Tatiana
Thank you for your question. Cirazoline hydrochloride is a selective AR (α1-Adrenoceptor) agonist that has been show to be involved in the induction of vasoconstriction. Here is a link to the PubChem page for this chemical compound where you can find additional information. https://pubchem.ncbi.nlm.nih.gov/compound/Cirazoline_hydrochloride#section=Depositor-Supplied-Synonyms
Answered by: Tech Service
Date published: 2016-09-26
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