Molecular structure of CIQ, CAS Number: 486427-17-2
CIQ (CAS 486427-17-2)
Alternate Names:
(3-chlorophenyl)[3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]-methanone
Application:
CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit
CAS Number:
486427-17-2
Molecular Weight:
467.94
Molecular Formula:
C26H26ClNO5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. This compound is shown to Increase channel opening efficiency and enhance NMDA receptor responses.
CIQ (CAS 486427-17-2) References
- Comparison of the CIQ and CHART Short Form in assessing community integration in individuals with chronic spinal cord injury: a pilot study. | Gontkovsky, ST., et al. 2009. NeuroRehabilitation. 24: 185-92. PMID: 19339757
- A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. | Mullasseril, P., et al. 2010. Nat Commun. 1: 90. PMID: 20981015
- GluN2C/GluN2D subunit-selective NMDA receptor potentiator CIQ reverses MK-801-induced impairment in prepulse inhibition and working memory in Y-maze test in mice. | Suryavanshi, PS., et al. 2014. Br J Pharmacol. 171: 799-809. PMID: 24236947
- An examination of the psychometric properties of the community integration questionnaire (CIQ) in spinal cord injury. | Kratz, AL., et al. 2015. J Spinal Cord Med. 38: 446-55. PMID: 24621050
- CIQ, a positive allosteric modulator of GluN2C/D-containing N-methyl-d-aspartate receptors, rescues striatal synaptic plasticity deficit in a mouse model of Parkinson's disease. | Nouhi, M., et al. 2018. CNS Neurosci Ther. 24: 144-153. PMID: 29230960
- Development of a customizable interactions questionnaire (CIQ) for evaluating interactions with objects in augmented/virtual reality. | Gao, M. and Boehm-Davis, DA. 2022. Virtual Real. 1-18. PMID: 36042785
Activator of:
NMDA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CIQ, 10 mg | sc-361150 | 10 mg | $145.00 | |||
| US: Only available in the US | ||||||
CIQ, 50 mg | sc-361150A | 50 mg | $645.00 | |||
| US: Only available in the US | ||||||