CIQ CAS: 486427-17-2
MF: C26H26ClNO5
MW: 467.94
A subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit.

CIQ (CAS 486427-17-2)

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Alternate Names: (3-chlorophenyl)[3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]-methanone
Application: CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit
CAS Number: 486427-17-2
Molecular Weight: 467.94
Molecular Formula: C26H26ClNO5
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

CIQ is a subunit-selective potentiator of NMDA receptors containing the NMDAε3 or NMDAε4 subunit. This compound is shown to Increase channel opening efficiency and enhance NMDA receptor responses.


References

1. Mullasseril, P., et al. 2010. Nat. Commun. 1: 1038-1085. PMID: 20981015

Physical State :
Solid
Solubility :
Soluble in DMSO (≥ 10 mg/ml, at warmed to 60 °C), and ethanol (10 mM with sonication).
Storage :
Store at -20° C
IC50 :
Increases channel opening frequency of recombinant NR2C containing receptors: EC5050 = 2.7 µM; Increases channel opening frequency of recombinant NR2D containing receptors: EC5050 = 2.8 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
Transport :
UN 3077, Class 9, Packing group III
PubChem CID :
4231127
SMILES :
COC1=CC=C(C=C1)OCC2C3=CC(=C(C=C3CCN2C(=O)C4=CC(=CC=C4)Cl)OC)OC

Download SDS (MSDS)

Certificate of Analysis

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