Molecular structure of Ciproxifan maleate, CAS Number: 184025-19-2
Ciproxifan maleate (CAS 184025-19-2)
Alternate Names:
Cyclopropyl (4-[3-(1H-imidazol-4-yl)propyloxy]phenyl) ketone maleate salt
Application:
Ciproxifan maleate is a potent and selective H3 histamine receptor antagonist
CAS Number:
184025-19-2
Purity:
>98%
Molecular Weight:
386.40
Molecular Formula:
C16H18N2O2•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ciproxifan maleate functions as a potent and selective histamine H3 receptor antagonist. It acts by binding to the histamine H3 receptor, inhibiting the binding of histamine and subsequently blocking the downstream signaling pathways. This interaction modulates the release of various neurotransmitters, including dopamine, acetylcholine, and norepinephrine, in the central nervous system.
Ciproxifan maleate (CAS 184025-19-2) References
- Reversal of oxidative stress by histamine H₃ receptor-ligands in experimental models of schizophrenia. | Mahmood, D., et al. 2012. Arzneimittelforschung. 62: 222-9. PMID: 22331799
- In vivo receptor occupancy assay of histamine H₃ receptor antagonist in rats using non-radiolabeled tracer. | Nirogi, R., et al. 2012. J Pharmacol Toxicol Methods. 65: 115-21. PMID: 22487318
- Protective effects of histamine H3-receptor ligands in schizophrenic behaviors in experimental models. | Mahmood, D., et al. 2012. Pharmacol Rep. 64: 191-204. PMID: 22580536
- Ciproxifan, a histamine H3 receptor antagonist, reversibly inhibits monoamine oxidase A and B. | Hagenow, S., et al. 2017. Sci Rep. 7: 40541. PMID: 28084411
- Chronic histamine 3 receptor antagonism alleviates depression like conditions in mice via modulation of brain-derived neurotrophic factor and hypothalamus-pituitary adrenal axis. | Kumar, A., et al. 2019. Psychoneuroendocrinology. 101: 128-137. PMID: 30458370
- Design, synthesis, and anticonvulsant effects evaluation of nonimidazole histamine H3 receptor antagonists/inverse agonists containing triazole moiety. | Song, M., et al. 2020. J Enzyme Inhib Med Chem. 35: 1310-1321. PMID: 32529860
- Short- and Long-Term Social Recognition Memory Are Differentially Modulated by Neuronal Histamine. | Rani, B., et al. 2021. Biomolecules. 11: PMID: 33918940
- Involvement of Histamine H3 Receptor Agonism in Premature Ejaculation Found by Studies in Rats. | Kiyohara, K., et al. 2022. Int J Mol Sci. 23: PMID: 35216402
- Ciproxifan attenuates the memory impairment induced by lipopolysaccharide through modulation of cholinergic transmission in the mouse brain. | Mani, V., et al. 2022. Eur Rev Med Pharmacol Sci. 26: 1897-1905. PMID: 35363338
- Genetically encoded sensors for measuring histamine release both in vitro and in vivo. | Dong, H., et al. 2023. Neuron. 111: 1564-1576.e6. PMID: 36924772
Inhibitor of:
Histamine H3 Receptor.Activator of:
Histamine H3 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ciproxifan maleate, 5 mg | sc-252608 | 5 mg | $146.00 |