Molecular structure of Ciproxifan hydrochloride, CAS Number: 1049741-81-2
Ciproxifan hydrochloride (CAS 1049741-81-2)
Application:
Ciproxifan hydrochloride is a novel chemical series of histamine H3-receptor antagonists
CAS Number:
1049741-81-2
Purity:
≥98%
Molecular Weight:
306.79
Molecular Formula:
C16H18N2O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ciproxifan belongs to a novel chemical series of histamine H3-receptor antagonists. In vitro, it behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. This appears to be an orally bioavailable, extremely selective and potent H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.
Ciproxifan hydrochloride (CAS 1049741-81-2) References
Ligneau, X., et al.,, Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist. J. Pharmacol. Exp. Ther. 287, 658-666, (1998)Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ciproxifan hydrochloride, 5 mg | sc-257245 | 5 mg | $200.00 |