Molecular structure of Ciprostene (calcium salt), CAS Number: 81703-55-1
Ciprostene (calcium salt) (CAS 81703-55-1)
Application:
Ciprostene (calcium salt) is a less potent, stable analog of PGI2
CAS Number:
81703-55-1
Molecular Weight:
769.1
Molecular Formula:
C44H72Ca2O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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This compound is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI2. It exhibits biological activity similar to PGI2, yet is 30-fold less potent. Ciprostene induces hypotension and causes tachycardia when administered at a dose of 0.16 µg/kg/min in patas monkeys.1 Also, ciprostene inhibits ADP-induced platelet aggregation ex vivo and in vitro with ID50 values of 9.1 µg/kg/min and 60 ng/ml, respectively.1,2
Ciprostene (calcium salt) (CAS 81703-55-1) References
- Use of prostacyclin and its analogues in the treatment of cardiovascular disease. | Fink, AN., et al. 1999. Heart Dis. 1: 29-40. PMID: 11720602
- Prostacyclin analogs inhibit fibroblast migration. | Kohyama, T., et al. 2002. Am J Physiol Lung Cell Mol Physiol. 283: L428-32. PMID: 12114205
- Ciprostene and indomethacin partially reverse the mechanisms of distal end necrosis in the rat random skin flap. | Salerno, GM., et al. 1992. Ann Plast Surg. 28: 526-33; discussion 534. PMID: 1622033
- Micro-quantitative determination of ciprostene in plasma by gas chromatography-mass spectrometry coupled with an antibody extraction. | Komatsu, S., et al. 1991. J Chromatogr. 568: 460-6. PMID: 1783651
- Rapakinin, Arg-Ile-Tyr, derived from rapeseed napin, shows anti-opioid activity via the prostaglandin IP receptor followed by the cholecystokinin CCK(2) receptor in mice. | Yamada, Y., et al. 2011. Peptides. 32: 281-5. PMID: 21129424
- Ciprostene, a stable prostacyclin analog, produces peripheral vasodilation, platelet inhibition and increased clot dissolution in the cat. | Schaub, RG. 1988. Prostaglandins. 35: 467-74. PMID: 3287459
- High-performance liquid chromatography method for the separation of isomers of 9 beta-methylcarbacyclin (ciprostene) and the analysis of pharmaceutical samples. | Theis, DL., et al. 1985. J Chromatogr. 321: 209-15. PMID: 3886680
- The cardiovascular and platelet actions of 9 beta-methyl carbacyclin (ciprostene), a chemically stable analogue of prostacyclin, in the dog and monkey. | Allan, G., et al. 1985. Br J Pharmacol. 85: 547-55. PMID: 3896365
- Activation of thromboxane and prostacyclin receptors elicits opposing effects on vascular smooth muscle cell growth and mitogen-activated protein kinase signaling cascades. | Jones, DA., et al. 1995. Mol Pharmacol. 48: 890-6. PMID: 7476920
- Continuous intravenous dosing with ciprostene using a portable pump in ambulatory patients. | Wolf, DL., et al. 1993. J Clin Pharmacol. 33: 150-3. PMID: 8440764
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ciprostene (calcium salt), 1 mg | sc-205247 | 1 mg | $146.00 | |||
Ciprostene (calcium salt), 5 mg | sc-205247A | 5 mg | $667.00 |