Cinoxacin CAS: 28657-80-9
MF: C12H10N2O5
MW: 262.22
An antibacterial quinolone.

Cinoxacin (CAS 28657-80-9)

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Synonym: Cinoxacino; Cinoxacinum; Clinoxacin
Application: An antibacterial quinolone
CAS Number: 28657-80-9
Purity: ≥99%
Molecular Weight: 262.22
Molecular Formula: C12H10N2O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Cinoxacin is an antibacterial quinolone analog of oxolinic acid. The compound has been documented to block DNA synthesis through inhibition of Topo II (DNA gyrase) as well as topoisomerase IV. Cinoxacin has been observed to block both topoisomerse IV in both prokaryotic and eukaryotic cell lines. Due to the inhibiting activity of Cinoxacin the compound has displayed toxicity against eukaryotic cells. In vitro studies have shown the renal damage caused by Cinoxacin to be attributed to deposition of Cinoxacin crystals in the urinary tract.


1. Sisca, T.S., et al. 1983. Drugs. 25: 544-569. PMID: 6347618
2. Drlica, K. and Zhao, X. 1997. Microbiol. Mol. Biol. Rev. 61: 377-392. PMID: 9293187

Appearance :
Physical State :
Solubility :
Soluble in alka line solutions (pH 10 or more), and most polar organic solvents.. Insoluble in water.
Storage :
Store at 4° C
Melting Point :
261-262° C
Boiling Point :
517.2° C at 760 mmHg (Predicted)
Density :
1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.71 (Predicted)
IC50 :
DNA gyrase: IC50 >262.22 nM (Escherichia coli K-12); Plasmodium falciparum 3D7: IC50 = 5.01 µM; Plasmodium falciparum: IC50 = 6.31 µM; PhoP regulon: IC50 = 27.94 µM (Salmonella Typhimurium)
pK Values :
pKb: 4.33 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 2309
MDL Number :
EC Number :
Beilstein Registry :

Download SDS (MSDS)

Certificate of Analysis

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