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CinnGEL 2Me is a cell-permeable protein tyrosine phosphatase-1B (PTP1B) inhibitor. PTP1B negatively regulates EGF-induced signaling and its inhibition reduces both Src kinase activity and colony formation of colon cancer cells. Research shows that PTP1B has the ability to suppress cell cycle entry.
1. Zhu, S., et al. 2007. Cancer Res. 67: 10129-10137. PMID: 17974954
2. Harris, D.L. and Joyce, N.C. 2007. Mol. Vis. 13: 785-796. PMID: 17563729
3. Ishino, Y., et al. 2008. Mol. Vis. 14: 61-70. PMID: 18253097
See how others have used CinnGEL 2-methylester. Click on the entry to view the PubMed entry .
PMID: # 25668475 Chamorro, ME. et al. 2015. Int. J. Biochem. Cell Biol. 61: 63-71.
PMID: # 22903352 Vota, DM. et al. 2013. Cell biochemistry and biophysics. 65: 145-57.
PMID: # 31831727 Nat Commun. 10: 5686.
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