Molecular structure of CinnGEL 2-methylester
CinnGEL 2-methylester
See product citations (5)
Application:
CinnGEL 2-methylester is a cell-permeable PTP1B inhibitor
Purity:
≥98%
Molecular Weight:
518.60
Molecular Formula:
C25H34N4O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
CinnGEL 2-methylester is a cell-permeable protein tyrosine phosphatase-1B (PTP1B) inhibitor, hydrolyzed to active inhibitor by intracellular esterases. PTP1B negatively regulates EGF-induced signaling and its inhibition reduces both Src kinase activity and colony formation of colon cancer cells. Research shows that PTP1B has the ability to suppress cell cycle entry.
CinnGEL 2-methylester References
- Protein tyrosine phosphatase, PTP1B, expression and activity in rat corneal endothelial cells. | Harris, DL. and Joyce, NC. 2007. Mol Vis. 13: 785-96. PMID: 17563729
- PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation. | Zhu, S., et al. 2007. Cancer Res. 67: 10129-37. PMID: 17974954
- Protein tyrosine phosphatase-1B (PTP1B) helps regulate EGF-induced stimulation of S-phase entry in human corneal endothelial cells. | Ishino, Y., et al. 2008. Mol Vis. 14: 61-70. PMID: 18253097
- Mechanisms for vascular cell adhesion molecule-1 activation of ERK1/2 during leukocyte transendothelial migration. | Abdala-Valencia, H., et al. 2011. PLoS One. 6: e26706. PMID: 22031842
- Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing. | Volta, F., et al. 2019. Nat Commun. 10: 5686. PMID: 31831727
Inhibitor of:
PTP1B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CinnGEL 2-methylester, 1 mg | sc-205633 | 1 mg | $245.00 |