CinnGEL 2-methylester MF: C25H34N4O8
MW: 518.60
A cell-permeable PTP1B inhibitor.

CinnGEL 2-methylester

CinnGEL 2-methylester is rated 5.0 out of 5 by 1.
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Application: A cell-permeable PTP1B inhibitor
Purity: ≥98%
Molecular Weight: 518.60
Molecular Formula: C25H34N4O8
* Refer to Certificate of Analysis for lot specific data (including water content).
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CinnGEL 2Me is a cell-permeable protein tyrosine phosphatase-1B (PTP1B) inhibitor. PTP1B negatively regulates EGF-induced signaling and its inhibition reduces both Src kinase activity and colony formation of colon cancer cells. Research shows that PTP1B has the ability to suppress cell cycle entry.


References

1. Zhu, S., et al. 2007. Cancer Res. 67: 10129-10137. PMID: 17974954
2. Harris, D.L. and Joyce, N.C. 2007. Mol. Vis. 13: 785-796. PMID: 17563729
3. Ishino, Y., et al. 2008. Mol. Vis. 14: 61-70. PMID: 18253097

Physical State :
Solid
Solubility :
Soluble in DMSO, and ethanol.
Storage :
Store at -20° C
IC50 :
PTP1B: IC50 = 1.3 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760038
SMILES :
CC(C)C[[email protected]@H](C(=O)N)NC(=O)[[email protected]](CCC(=O)OC)NC(=O)CNC(=O)C1=CC=C(C=C1)/C=C/C(=O)OC

Download SDS (MSDS)

Certificate of Analysis

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CinnGEL 2-methylester  Product Citations

See how others have used CinnGEL 2-methylester. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 25668475  Chamorro, ME. et al. 2015. Int. J. Biochem. Cell Biol. 61: 63-71.

PMID: # 22903352  Vota, DM. et al. 2013. Cell biochemistry and biophysics. 65: 145-57.

PMID: # 31831727  Nat Commun. 10: 5686.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Working well in my experiments Working well in my experiments, good information in datasheet.
Date published: 2015-05-04
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