Molecular structure of Cinacalcet Hydrochloride, CAS Number: 364782-34-3
Cinacalcet Hydrochloride (CAS 364782-34-3)
See product citations (7)
Alternate Names:
(αR)-α-Methyl-N-[3-[3-(trifluoromethyl)phenyl)propyl]-1-napthalenemethanamine Hydrochloride; (R)-N-(3-(3-(trifluoromethyl)phenyl)propyl)-1- -(1-napthyl)ethylamine Hydrochloride; Mimpara; Sensipar
Application:
Cinacalcet Hydrochloride is an allosteric activator of CaSR
CAS Number:
364782-34-3
Purity:
≥99%
Molecular Weight:
393.87
Molecular Formula:
C22H23ClF3N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cinacalcet Hydrochloride is a type II calcimimetic agent which controls calcium levels in cells by allosteric activation of CaSR (calcium sensing receptors). Studies show that Cinacalcet Hydrochloride affects cell proliferation in CHO cells transfected with CaSRs. In addition, it is known that Cinacalcet Hydrochloride inhibits the secretion of the parathyroid hormone (PTH). These studies suggest that Cinacalcet Hydrochloride in instrumental in increasing the cytoplasmic concentration of Ca2+. Furthermore, Cinacalcet Hydrochloride is an analog of NPS R-568 which contains a much better metabolic profile.
Cinacalcet Hydrochloride (CAS 364782-34-3) References
- Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl. | Nemeth, EF., et al. 2004. J Pharmacol Exp Ther. 308: 627-35. PMID: 14593085
- In vitro studies with the calcimimetic, cinacalcet HCl, on normal human adult osteoblastic and osteoclastic cells. | Shalhoub, V., et al. 2003. Crit Rev Eukaryot Gene Expr. 13: 89-106. PMID: 14696958
- Effects of calcimimetic on vascular calcification and atherosclerosis in uremic mice. | Joki, N., et al. 2009. Bone. 45 Suppl 1: S30-4. PMID: 19303957
- The extracellular calcium-sensing receptor is required for cholecystokinin secretion in response to L-phenylalanine in acutely isolated intestinal I cells. | Liou, AP., et al. 2011. Am J Physiol Gastrointest Liver Physiol. 300: G538-46. PMID: 21252045
- Cinacalcet HCl suppresses Cyclin D1 oncogene-derived parathyroid cell proliferation in a murine model for primary hyperparathyroidism. | Imanishi, Y., et al. 2011. Calcif Tissue Int. 89: 29-35. PMID: 21541686
- Development and Validation of a Stability-Indicating RP-UPLC Method for the Estimation of Impurities in Cinacalcet Hydrochloride API and its Formulation. | Sunil Reddy, P., et al. 2015. Sci Pharm. 83: 583-98. PMID: 26839840
- Cinacalcet corrects hypercalcemia in mice with an inactivating Gα11 mutation. | Howles, SA., et al. 2017. JCI Insight. 2: PMID: 29046478
- Osteoclast-Released Wnt-10b Underlies Cinacalcet Related Bone Improvement in Chronic Kidney Disease. | Zheng, CM., et al. 2019. Int J Mol Sci. 20: PMID: 31181716
- Studies on potential interaction between cinacalcet hydrochloride and diclofenac sodium. | Hamdan, II., et al. 2020. Biophys Chem. 266: 106460. PMID: 32890944
- Repurposing calcium-sensing receptor agonist cinacalcet for treatment of CFTR-mediated secretory diarrheas. | Oak, AA., et al. 2021. JCI Insight. 6: PMID: 33400691
- Characterization of Ca2+-Sensing Receptor-Mediated Ca2+ Influx in Microvascular bEND.3 Endothelial Cells. | Leong, IL., et al. 2021. Chin J Physiol. 64: 80-87. PMID: 33938818
- Cinacalcet Improves Bone Parameters Through Regulation of Osteoclast Endoplasmic Reticulum Stress, Autophagy, and Apoptotic Pathways in Chronic Kidney Disease-Mineral and Bone Disorder. | Chiu, HW., et al. 2022. J Bone Miner Res. 37: 215-225. PMID: 34633122
- The calcium-sensing receptor stabilizes podocyte function in proteinuric humans and mice. | Mühlig, AK., et al. 2022. Kidney Int. 101: 1186-1199. PMID: 35271934
- Neurorescuing effect of Cinacalcet against hypercalcemia-induced nerve injury in chronic kidney disease via TRAF2/cIAP1/KLF2/SERPINA3 signal axis. | Cao, Y., et al. 2022. Cell Biol Toxicol.. PMID: 35635602
- Sensitivity of Ca2+-sensing receptor-transient receptor potential-mediated Ca2+ influx to extracellular acidity in bEND.3 endothelial cells. | Leong, IL., et al. 2022. Chin J Physiol. 65: 277-281. PMID: 36588353
Activator of:
CaSR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cinacalcet Hydrochloride, 10 mg | sc-207438 | 10 mg | $230.00 |