Molecular structure of Cilazapril, CAS Number: 88768-40-5
Cilazapril (CAS 88768-40-5)
Alternate Names:
(1S,9S)-9-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic Acid; Ro 31-2848; Vascace
Application:
Cilazapril is a potent ACE inhibitor
CAS Number:
88768-40-5
Molecular Weight:
417.50
Molecular Formula:
C22H31N3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cilazapril is a monoethyl ester, which acts as an angiotensin-converting enzyme (ACE) inhibitor. The inhibitor functions by inhibiting the the ability of ACE to cleave bonds of angiotensin I and Hip-His-Leu. It is known that the diacid form of Cilazapril is more potent that enalapril at inhibiting ACE. Studies on hypertensive rats indicate that Cilazapril can decrease aortic blood pressure in arterial and venous blood vessels. It is known that Cilazapril is hydrolyzed to its active acid metabolite, Cilazaprilat (sc-207436) by non-specific esterases.
Cilazapril (CAS 88768-40-5) References
- Biological properties of the angiotensin-converting enzyme inhibitor cilazapril. | Natoff, IL., et al. 1985. J Cardiovasc Pharmacol. 7: 569-80. PMID: 2410692
- Vascular angiotensin converting enzyme activity in spontaneously hypertensive rats and its inhibition with cilazapril. | Nakamura, Y., et al. 1988. J Hypertens. 6: 105-10. PMID: 2832472
- Lignin-Based Spherical Structures and Their Use for Improvement of Cilazapril Stability in Solid State. | Stanisz, M., et al. 2020. Molecules. 25: PMID: 32660132
- How Does Glycation Affect Binding Parameters of the Albumin-Gliclazide System in the Presence of Drugs Commonly Used in Diabetes? In Vitro Spectroscopic Study. | Wiglusz, K., et al. 2021. Molecules. 26: PMID: 34202801
- Immunomodulatory Activity of the Most Commonly Used Antihypertensive Drugs-Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers. | Bryniarski, P., et al. 2022. Int J Mol Sci. 23: PMID: 35163696
- l-Ornithine-N5-monooxygenase (PvdA) Substrate Analogue Inhibitors for Pseudomonas aeruginosa Infections Treatment: Drug Repurposing Computational Studies. | Rosy, JC., et al. 2022. Biomolecules. 12: PMID: 35883443
- Protolytic equilibria of ACE inhibitors in micellar solution of nonionic surfactant Brij 35. | Popović-Nikolić, MR., et al. 2023. Monatsh Chem. 154: 615-624. PMID: 37193115
- Angiotensin-converting enzyme inhibitor induced cough compared with placebo, and other antihypertensives: A systematic review, and network meta-analysis. | Hu, Y., et al. 2023. J Clin Hypertens (Greenwich). 25: 661-688. PMID: 37417783
- Network pharmacology combined with Mendelian randomization analysis to identify the key targets of renin-angiotensin-aldosterone system inhibitors in the treatment of diabetic nephropathy. | Zhou, D., et al. 2024. Front Endocrinol (Lausanne). 15: 1354950. PMID: 38332893
- Cilazapril reverses endothelium-dependent vasodilator response to acetylcholine in mesenteric artery from spontaneously hypertensive rats. | Young, RH., et al. 1995. Am J Hypertens. 8: 928-33. PMID: 8541009
Inhibitor of:
ACE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cilazapril, 10 mg | sc-207435 | 10 mg | $300.00 |