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Cilastatin sodium (CAS 81129-83-1)

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Alternate Names:
[R-[R*,S*-(Z)]]-7-[(2-Amino-2-carboxyethyl)thio]-2- [[(2,2-dimethylcyclopropyl)carbonyl]amino]-2- heptenoic acid monosodium salt
Application:
Cilastatin sodium is a dipeptidase inhibitor with nephroprotective effects
CAS Number:
81129-83-1
Purity:
≥98%
Molecular Weight:
380.43
Molecular Formula:
C16H25N2O5S•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cilastatin sodium is utilized in biochemical research to investigate the inhibition of human renal enzymes, particularly renal dehydropeptidase-1 (DHP-1). DHP-1 is involved in the metabolic breakdown of certain antibiotics, and cilastatin is studied for its ability to protect these compounds from enzymatic degradation. In experimental applications, researchers use cilastatin sodium to delve into the mechanisms of renal metabolism and to assess how the inhibition of DHP-1 can affect the kinetics and mechanisms of compounds simultaneously administered. This research has broader implications for improving chemical delivery systems and understanding renal clearance. Its use in research extends to the examination of kidney function and the exploration of how endogenous compounds are processed by renal pathways.


Cilastatin sodium (CAS 81129-83-1) References

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  2. Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis.  |  Nitanai, Y., et al. 2002. J Mol Biol. 321: 177-84. PMID: 12144777
  3. Cilastatin protection against cyclosporin A-induced nephrotoxicity: clinical evidence.  |  Tejedor, A., et al. 2007. Curr Med Res Opin. 23: 505-13. PMID: 17355732
  4. Cilastatin attenuates cisplatin-induced proximal tubular cell damage.  |  Camano, S., et al. 2010. J Pharmacol Exp Ther. 334: 419-29. PMID: 20435919
  5. Cost-effectiveness model of empiric doripenem compared with imipenem-cilastatin in ventilator-associated pneumonia.  |  Zilberberg, MD., et al. 2010. Surg Infect (Larchmt). 11: 409-17. PMID: 20666580
  6. A multicenter, randomized controlled clinical study on biapenem and imipenem/cilastatin injection in the treatment of respiratory and urinary tract infections.  |  Jia, B., et al. 2010. Chemotherapy. 56: 285-90. PMID: 20714145
  7. Cilastatin-insulin interaction in the rat.  |  Tompkins, GC., et al. 1989. Drug Metab Dispos. 17: 54-7. PMID: 2566470
  8. Lipid imaging for visualizing cilastatin amelioration of cisplatin-induced nephrotoxicity.  |  Moreno-Gordaliza, E., et al. 2018. J Lipid Res. 59: 1561-1574. PMID: 30049708
  9. FKBP51, AmotL2 and IQGAP1 Involvement in Cilastatin Prevention of Cisplatin-Induced Tubular Nephrotoxicity in Rats.  |  González-Fernández, R., et al. 2022. Cells. 11: PMID: 35563891
  10. The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA.  |  Keynan, S., et al. 1995. Antimicrob Agents Chemother. 39: 1629-31. PMID: 7492120
  11. Aerosolization of imipenem/cilastatin prevents pseudomonas-induced acute lung injury.  |  Hashimoto, S., et al. 1996. J Antimicrob Chemother. 38: 809-18. PMID: 8961050
  12. Dipeptidase inhibitor and epithelial removal potentiate leukotriene D4-induced human tracheal smooth muscle contraction.  |  Yamaya, M., et al. 1998. Respir Physiol. 111: 101-9. PMID: 9496476
  13. Effects of fosfomycin and imipenem/cilastatin on nephrotoxicity and renal excretion of vancomycin in rats.  |  Nakamura, T., et al. 1998. Pharm Res. 15: 734-8. PMID: 9619782

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cilastatin sodium, 10 mg

sc-201312
10 mg
$285.00

Cilastatin sodium, 50 mg

sc-201312A
50 mg
$715.00