CIDE-C Antibody (7C12F11): sc-517232

CIDE-C Antibody (7C12F11) is a mouse monoclonal IgG1 antibody that detects CIDE-C protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-CIDE-C antibody (7C12F11) is available as a non-conjugated format. CIDE-C protein, also known as cell death-inducing DFFA-like effector-c, CIDE-3, or Fsp27, is a 238 amino acid protein that plays a crucial role in regulating apoptosis and lipid metabolism. CIDE-C protein is predominantly expressed in the small intestine, colon, heart, and stomach, with lower levels found in the liver, brain, and kidney. CIDE-C protein is localized in the cytoplasm and contains a CIDE-N domain, which is essential for promoting programmed cell death. Notably, CIDE-C exists as three alternatively spliced isoforms, two of which are implicated in the induction of apoptosis, highlighting its importance in cellular homeostasis and response to stress. CIDE-C protein is upregulated during adipogenesis in both white and brown adipose tissues, suggesting a role in negatively regulating lipolysis and promoting triglyceride accumulation, which is significant for understanding metabolic disorders. CIDE-C gene is located on human chromosome 3, a region that encompasses over 1,100 genes, including those associated with various cancers and a chemokine receptor gene cluster, underscoring potential implications in both metabolic and oncogenic pathways.

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CIDE-C Antibody (7C12F11) References:

1. Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family.  |  Liang, L., et al. 2003. Biochem J. 370: 195-203. PMID: 12429024
2. Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage.  |  Puri, V., et al. 2007. J Biol Chem. 282: 34213-8. PMID: 17884815
3. Fat-specific protein 27 regulates storage of triacylglycerol.  |  Keller, P., et al. 2008. J Biol Chem. 283: 14355-65. PMID: 18334488
4. Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27.  |  Matsusue, K., et al. 2008. Cell Metab. 7: 302-11. PMID: 18396136
5. Cidea is associated with lipid droplets and insulin sensitivity in humans.  |  Puri, V., et al. 2008. Proc Natl Acad Sci U S A. 105: 7833-8. PMID: 18509062
6. Redistribution of cell death-inducing DNA fragmentation factor-like effector-a (CIDEa) from mitochondria to nucleus is associated with apoptosis in HeLa cells.  |  Valousková, E., et al. 2008. Gen Physiol Biophys. 27: 92-100. PMID: 18645223
7. Cell death-inducing DFF45-like effector C is reduced by caloric restriction and regulates adipocyte lipid metabolism.  |  Magnusson, B., et al. 2008. Metabolism. 57: 1307-13. PMID: 18702959
8. Evidence for an important role of CIDEA in human cancer cachexia.  |  Laurencikiene, J., et al. 2008. Cancer Res. 68: 9247-54. PMID: 19010897

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CIDE-C Antibody (7C12F11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CIDE-C Antibody (7C12F11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CIDE-C Antibody (7C12F11) Specifications

Alternate Product Name: CIDE-C

Product Clone Name: 7C12F11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 53-141

Epitope Target: CIDE-C

Epitope Species: human

Product Reactivity/Detection: CIDE-C

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM, ELISA

Vialing Information: Each vial contains 50 µg IgG₁ in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CIDE-C Antibody (7C12F11): N/A