Molecular structure of Cicaprost, CAS Number: 94079-80-8
Cicaprost (CAS 94079-80-8)
Application:
Cicaprost is A PGI2 (prostacyclin) analog and IP receptor agonist
CAS Number:
94079-80-8
Purity:
≥98%
Molecular Weight:
374.48
Molecular Formula:
C22H30O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
Cicaprost is a PGI2 analog which causes prostacyclin receptor (IP) activation. The activation of IP by this compound is associated with phosphorylation of transcription factor cAMP response element binding protein as well as cAMP elevation. Experiments suggest that Cicaprost also contains strong anti-mitogenic characteristics and can regulate the p27(kip1) levels in cells.
Cicaprost (CAS 94079-80-8) References
- Pharmacokinetics of iloprost and cicaprost in mice. | Hildebrand, M. 1992. Prostaglandins. 44: 431-42. PMID: 1281921
- Mechanism of cicaprost-induced desensitization in rat pulmonary artery smooth muscle cells involves a PKA-mediated inhibition of adenylyl cyclase. | Sobolewski, A., et al. 2004. Am J Physiol Lung Cell Mol Physiol. 287: L352-9. PMID: 15107293
- Evidence that inward rectifier K+ channels mediate relaxation by the PGI2 receptor agonist cicaprost via a cyclic AMP-independent mechanism. | Orie, NN., et al. 2006. Cardiovasc Res. 69: 107-15. PMID: 16183044
- Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells. | Zhou, W., et al. 2007. J Immunol. 178: 702-10. PMID: 17202330
- Prostacyclin receptor suppresses cardiac fibrosis: role of CREB phosphorylation. | Chan, EC., et al. 2010. J Mol Cell Cardiol. 49: 176-85. PMID: 20403362
- Cell-type- and cell-cycle-specific anti-mitogenesis by cicaprost. | Castagnino, P., et al. 2010. Prostaglandins Other Lipid Mediat. 93: 20-4. PMID: 20457271
- Pharmacokinetics and pharmacodynamics of cicaprost in healthy volunteers after oral administration of 5 to 20 micrograms. | Hildebrand, M., et al. 1990. Eur J Clin Pharmacol. 39: 149-53. PMID: 2253664
- Pharmacokinetics of 3H-cicaprost in healthy volunteers. | Hildebrand, M., et al. 1989. Prostaglandins. 37: 259-73. PMID: 2657866
- The PGI2 Analog Cicaprost Inhibits IL-33-Induced Th2 Responses, IL-2 Production, and CD25 Expression in Mouse CD4+ T Cells. | Zhou, W., et al. 2018. J Immunol. 201: 1936-1945. PMID: 30127087
- Cicaprost inhibits collagen-induced platelet accumulation in rat lungs for some hours. | Nowak, G. and Bucha, E. 1995. Agents Actions Suppl. 45: 101-6. PMID: 7536381
- Development and validation of a sensitive and specific radioimmunoassay for the determination of cicaprost in biological samples. | Hildebrand, M., et al. 1994. J Immunoassay. 15: 171-90. PMID: 8040351
- The stable prostacyclin analogue Cicaprost inhibits metastasis to lungs and lymph nodes in the 13762NF MTLn3 rat mammary carcinoma. | Schirner, M., et al. 1994. Clin Exp Metastasis. 12: 24-30. PMID: 8287616
- Antimetastatic action of the prostacyclin analogue cicaprost in experimental mammary tumors. | Schneider, MR., et al. 1996. Breast Cancer Res Treat. 38: 133-41. PMID: 8825130
Activator of:
IP Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cicaprost, 500 µg | sc-358799 | 500 µg | $638.00 | |||
Cicaprost, 1 mg | sc-358799A | 1 mg | $1230.00 |