Molecular structure of CI 976, CAS Number: 114289-47-3
CI 976 (CAS 114289-47-3)
See product citations (4)
Alternate Names:
2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
Application:
CI 976 is a trimethoxy fatty acid anilide inhibitor of ACAT/SOAT
CAS Number:
114289-47-3
Purity:
≥98%
Molecular Weight:
393.57
Molecular Formula:
C23H39NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CI 976 is a trimethoxy fatty acid anilide inhibitor of liver and intestinal acyl coenzyme A cholesterol acyltransferase (ACAT) and sterol O-acyltransferase (SOAT). Cl 976 lowers non-high density lipoprotein (non-HDL) cholesterol and increases HDL-cholesterol concentrations. This innovative molecule is a derivative of dodecanamide, a 12-carbon fatty acid, and showcases a unique molecular structure containing two methyl groups, two methoxy groups, and a phenyl group. The primary focus of research on CI 976 lies in its ability to influence enzymes and receptors, suggesting promising applications as an anti-inflammatory agent. Although the precise mechanism of action remains partially elusive, experts theorize that CI 976 may interact with cellular pathways like the PI3K/Akt/mTOR pathway, which governs cell growth and survival.
CI 976 (CAS 114289-47-3) References
- Characterization of a novel CI-976-sensitive lysophospholipid acyltransferase that is associated with the Golgi complex. | Chambers, K. and Brown, WJ. 2004. Biochem Biophys Res Commun. 313: 681-6. PMID: 14697244
- Effect of the ACAT inhibitor CI-976 on plasma cholesterol concentrations and distribution in hamsters fed zero- and low-cholesterol diets. | Krause, BR., et al. 1992. Clin Biochem. 25: 371-7. PMID: 1490301
- A unique lysophospholipid acyltransferase (LPAT) antagonist, CI-976, affects secretory and endocytic membrane trafficking pathways. | Chambers, K., et al. 2005. J Cell Sci. 118: 3061-71. PMID: 15972316
- The lysophospholipid acyltransferase antagonist CI-976 inhibits a late step in COPII vesicle budding. | Brown, WJ., et al. 2008. Traffic. 9: 786-97. PMID: 18331383
- Optimal contrast medium injection protocols for the depiction of the Adamkiewicz artery using 64-detector CT angiography. | Nakayama, Y., et al. 2008. Clin Radiol. 63: 880-7. PMID: 18625352
- Iron loaded ferritin secretion and inhibition by CI-976 in Aedes aegypti larval cells. | Geiser, DL., et al. 2009. Comp Biochem Physiol B Biochem Mol Biol. 152: 352-63. PMID: 19168145
- Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions. A biochemical, morphological, and morphometric evaluation. | Bocan, TM., et al. 1991. Arterioscler Thromb. 11: 1830-43. PMID: 1931885
- A lysophospholipid acyltransferase antagonist, CI-976, creates novel membrane tubules marked by intracellular phospholipase A1 KIAA0725p. | Baba, T., et al. 2013. Mol Cell Biochem. 376: 151-61. PMID: 23378048
- Blocking cholesterol efflux mechanism is a potential target for antilymphoma therapy. | Yano, H., et al. 2022. Cancer Sci. 113: 2129-2143. PMID: 35343027
- Cholesterol metabolism and lipid droplet vacuoles; a potential target for the therapy of aggressive lymphoma. | Yano, H., et al. 2022. J Clin Exp Hematop. 62: 190-194. PMID: 36436934
- [Hyperuricemia among Mongolian adults and the related factors in Inner Mongolia Autonomous Region from 2018 to 2020]. | Dong, J., et al. 2022. Wei Sheng Yan Jiu. 51: 940-946. PMID: 36539870
- Biodisposition studies with the acyl-coenzyme A: cholesterol acyltransferase inhibitor 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide, CI-976. | Woolf, TF., et al. 1993. Drug Metab Dispos. 21: 1112-8. PMID: 7905392
- Determination of 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl) dodecanamide, CI-976, in rat plasma by reversed-phase high-performance liquid chromatography. | Shum, YY., et al. 1994. J Chromatogr B Biomed Appl. 653: 205-9. PMID: 8205247
- In vivo evidence that the lipid-regulating activity of the ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT. | Krause, BR., et al. 1993. J Lipid Res. 34: 279-94. PMID: 8429262
- In vitro and in vivo disposition of 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide (CI-976). Identification of a novel five-carbon cleavage metabolite in rats. | Sinz, MW., et al. 1997. Drug Metab Dispos. 25: 123-30. PMID: 9010639
Inhibitor of:
ACAP1, ACAT, ACAT-3, LPAAT-δ, Peroxin 10, Rab 11A, SOAT, and SOAT1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CI 976, 5 mg | sc-203892B | 5 mg | $107.00 | |||
CI 976, 10 mg | sc-203892 | 10 mg | $185.00 | |||
CI 976, 50 mg | sc-203892A | 50 mg | $759.00 |