CHT1 Antibody (CT1): sc-52520
- CHT1 Antibody (CT1) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against thymocytes of chicken origin
- recommended for detection of CHT1 antigen on chicken thymocytes of avian origin by IP and FCM
- available conjugated to phycoerythrin for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CHT1 Antibody (CT1). This work is in progress.
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CHT1 Antibody (CT1) is a mouse monoclonal IgG1 antibody that detects choline transporter 1 (CHT1) in avian species through applications such as immunoprecipitation (IP) and flow cytometry (FCM). CHT1 plays a crucial role in the regulation of acetylcholine synthesis by mediating the high-affinity uptake of choline in cholinergic neurons, which is essential for neurotransmission and overall nervous system function. CHT1 is predominantly localized in cholinergic presynaptic terminals, where CHT1 is found in a specific subset of small vesicles that also contain vesicular acetylcholine transporter and acetylcholine. The strategic localization of CHT1 within these vesicles allows for efficient re-uptake of choline in response to neuronal activity, thereby influencing the rate of acetylcholine release and maintaining synaptic transmission. The importance of CHT1 in cholinergic signaling highlights CHT1′s potential as a target for studying various neurological conditions and developing therapeutic strategies. Anti-CHT1 antibody (CT1) is an invaluable tool for researchers investigating the dynamics of cholinergic neurotransmission in avian models.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CHT1 Antibody (CT1) References:
- Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane. | Xie, J. and Guo, Q. 2004. J Biol Chem. 279: 28266-75. PMID: 15090548
- Choline transport for phospholipid synthesis. | Michel, V., et al. 2006. Exp Biol Med (Maywood). 231: 490-504. PMID: 16636297
- Regulated recycling and plasma membrane recruitment of the high-affinity choline transporter. | Ribeiro, FM., et al. 2007. Eur J Neurosci. 26: 3437-48. PMID: 18088276
- Acetylcholine synthesis and release in NIH3T3 cells coexpressing the high-affinity choline transporter and choline acetyltransferase. | Fujii, T., et al. 2009. J Neurosci Res. 87: 3024-32. PMID: 19405101
- Nuclear choline acetyltransferase activates transcription of a high-affinity choline transporter. | Matsuo, A., et al. 2011. J Biol Chem. 286: 5836-45. PMID: 21163949
- The non-neuronal cholinergic system in the heart: A comprehensive review. | Saw, EL., et al. 2018. J Mol Cell Cardiol. 125: 129-139. PMID: 30343172
- Targeted demethylation of the SLC5A7 promotor inhibits colorectal cancer progression. | Li, Y., et al. 2022. Clin Epigenetics. 14: 92. PMID: 35858918
- Biochemical characterization of two novel mutations in the human high-affinity choline transporter 1 identified in a patient with congenital myasthenic syndrome. | Rizvi, M., et al. 2023. Hum Mol Genet. 32: 1552-1564. PMID: 36611016
- CDP-choline modulates cholinergic signaling and gut microbiota to alleviate DSS-induced inflammatory bowel disease. | Guo, L., et al. 2023. Biochem Pharmacol. 217: 115845. PMID: 37827341
- Electroacupuncture regulates Rab5a-mediating NGF transduction to improve learning and memory ability in the early stage of AD mice. | Li, J., et al. 2024. CNS Neurosci Ther. 30: e14743. PMID: 38780008
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CHT1 Antibody (CT1) | sc-52520 | 100 µg/ml | $322.00 |