Chrysamine G, a lipophilic derivative and carboxylic acid analog of Congo red (sc-359843), has been shown to bind to the β-amyloid protein in vitro. Binding to the β-amyloid protein has been reported to inhibit its neurodegenerative activity. Studies suggest that Chrysamine G inhibits β-amyloid due to its antioxidant acitvity.
1. Klunk, W.E., et al. 1995. Neurobiol. Aging. 16: 541-548. PMID: 8544903 2. Klunk, W.E., et al. 1998. Life Sci. 63: 1807-1814. PMID: 9820124 3. Ishii, K., et al. 2002. Neurosci. Lett. 333: 5-8. PMID: 12401547
Soluble in DMSO (1 mg/ml).
Store at 4° C
328.25° C (Predicted)
814.24° C at 760 mmHg (Predicted)
1.42 g/cm3 (Predicted)
n20D 1.69 (Predicted)
β-Amyloid: Ki= 0.14 nM (human)
pKa: 2.71 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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