Chr-B Antibody (32): sc-517541

Chr-B Antibody (32) is a mouse monoclonal IgG1 antibody that detects Chr-B protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Chr-B antibody (32) is available as a non-conjugated isotype antibody. Chr-B protein, also known as chromogranin B or secretogranin I, plays a crucial role in the storage and release of neuropeptides and hormones within secretory granules of neuroendocrine and endocrine cells. Chr-B (32) monoclonal antibody is essential for studying proper neuroendocrine signaling, as Chr-B helps regulate the secretion of various bioactive peptides, including pancreastatin, which is derived from chromogranin A and inhibits insulin secretion. Chr-B presence in secretory granules is vital for maintaining the balance of hormonal release, and dysregulation can lead to various neuroendocrine disorders. Additionally, Chr-B interaction with other proteins, such as carboxypeptidase E, highlights its importance in the processing and sorting of secretory proteins, further emphasizing its role in neuroendocrine function. Anti-Chr-B antibody (32) is an invaluable tool for researchers studying neuroendocrine signaling pathways and related diseases.

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Chr-B Antibody (32) References:

1. Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells.  |  Hosaka, M., et al. 2002. Mol Biol Cell. 13: 3388-99. PMID: 12388744
2. Immunocytochemical localization of secretogranin III in the anterior lobe of male rat pituitary glands.  |  Sakai, Y., et al. 2003. J Histochem Cytochem. 51: 227-38. PMID: 12533531
3. Differential regulation of chromogranin B/secretogranin I and secretogranin II by forskolin in PC12 cells.  |  Thompson, ME., et al. 1992. Brain Res Mol Brain Res. 12: 195-202. PMID: 1312201
4. Immunolocalization of secretogranin II, chromogranin A, and chromogranin B in differentiating human neuroblastoma cells.  |  Giudici, AM., et al. 1992. Eur J Cell Biol. 58: 383-9. PMID: 1425774
5. Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A.  |  Hosaka, M., et al. 2004. J Biol Chem. 279: 3627-34. PMID: 14597614
6. Interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting within secretory granules.  |  Hosaka, M., et al. 2005. J Cell Sci. 118: 4785-95. PMID: 16219686
7. Distribution of chromogranin A and secretogranin I (chromogranin B) in neuroendocrine cells and tumors.  |  Lloyd, RV., et al. 1988. Am J Pathol. 130: 296-304. PMID: 3341449
8. Measurements of chromogranin A, chromogranin B (secretogranin I), chromogranin C (secretogranin II) and pancreastatin in plasma and urine from patients with carcinoid tumours and endocrine pancreatic tumours.  |  Stridsberg, M., et al. 1995. J Endocrinol. 144: 49-59. PMID: 7891024
9. Immunohistochemical demonstration of chromogranin A, chromogranin B, and secretogranin II in extra-adrenal paragangliomas.  |  Schmid, KW., et al. 1994. Mod Pathol. 7: 347-53. PMID: 8058707
10. Current status on chromogranin A and pancreastatin.  |  Robberecht, P., et al. 1993. Acta Gastroenterol Belg. 56: 261-3. PMID: 8266767
11. Chromogranin A, secretogranin II and vasoactive intestinal peptide in phaeochromocytomas and ganglioneuromas.  |  Schmid, KW., et al. 1993. Histopathology. 22: 527-33. PMID: 8354485
12. Histamine induces a gene-specific synthesis regulation of secretogranin II but not of chromogranin A and B in chromaffin cells in a calcium-dependent manner.  |  Bauer, JW., et al. 1993. J Biol Chem. 268: 1586-9. PMID: 8420933

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Chr-B Antibody (32) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Chr-B Antibody (32) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Chr-B Antibody (32) Specifications

Alternate Product Name: Chromogranin B

Product Clone Name: 32

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 200-389

Epitope Target: Chr-B

Epitope Species: rat

Product Reactivity/Detection: Chr-B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Chr-B Antibody (32): N/A