Chr-A Antibody (PHE5): sc-53013

Chr-A Antibody (PHE5) is a mouse monoclonal IgG1 antibody that detects chromogranin A (Chr-A) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Chr-A is an acidic glycoprotein predominantly localized within secretory granules of neuroendocrine and endocrine tissues, playing a crucial role in the storage and release of hormones and neuropeptides. Elevated levels of Chr-A are often associated with neuroendocrine tumors, making Chr-A a valuable biomarker for diagnosis and monitoring of these malignancies. Chr-A is the precursor to several biologically active peptides, including pancreastatin, which regulates insulin and gastric acid secretion, highlighting Chr-A′s importance in metabolic processes. Chr-A′s ability to interact with other proteins, such as carboxypeptidase E, further emphasizes Chr-A′s role in the complex network of neuroendocrine signaling. Anti-Chr-A antibody (PHE5) provides robust reactivity and versatility in various applications, serving as an essential tool for researchers investigating neuroendocrine function and pathology.

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Chr-A Antibody (PHE5) References:

1. Chromogranin A immunoreactivity compared with argyrophilia, calcitonin immunoreactivity, and amyloid as tumour markers in the histopathological diagnosis of medullary (C-cell) thyroid carcinoma.  |  Harach, HR., et al. 1992. Pathol Res Pract. 188: 123-30. PMID: 1594480
2. Prognostic impact of histologic demonstration of chromogranin A and neuron specific enolase in pulmonary adenocarcinoma.  |  Skov, BG., et al. 1991. Ann Oncol. 2: 355-60. PMID: 1954180
3. Chromogranin A: osmotically active fragments and their susceptibility to proteolysis during lysis of the bovine chromaffin granules.  |  Helle, KB., et al. 1990. Acta Physiol Scand. 138: 565-74. PMID: 2191538
4. Chromogranin A as a marker of neuroendocrine histogenesis of tumours: an immunoelectron microscopic study with considerations about the influence of fixation and embedding media on immunolabelling.  |  Leone, BE., et al. 1990. Basic Appl Histochem. 34: 143-53. PMID: 2222401
5. Plasma chromogranin-A in primary hyperparathyroidism.  |  Nanes, MS., et al. 1989. J Clin Endocrinol Metab. 69: 950-5. PMID: 2571619
6. [Chromogranin A derived peptide CGA47-66 inhibits hyper-permeability of blood brain barrier in mice with sepsis].  |  Zeng, Y., et al. 2016. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 28: 122-6. PMID: 26911943
7. Chrysomycin A Attenuates Neuroinflammation by Down-Regulating NLRP3/Cleaved Caspase-1 Signaling Pathway in LPS-Stimulated Mice and BV2 Cells.  |  Liu, M., et al. 2021. Int J Mol Sci. 22: PMID: 34202695
8. Chrysomycin A Inhibits the Proliferation, Migration and Invasion of U251 and U87-MG Glioblastoma Cells to Exert Its Anti-Cancer Effects.  |  Liu, DN., et al. 2022. Molecules. 27: PMID: 36234681
9. Chrysomycin A Regulates Proliferation and Apoptosis of Neuroglioma Cells via the Akt/GSK-3β Signaling Pathway In Vivo and In Vitro.  |  Liu, DN., et al. 2023. Mar Drugs. 21: PMID: 37367654
10. Chrysomycin A Reshapes Metabolism and Increases Oxidative Stress to Hinder Glioblastoma Progression.  |  Liu, DN., et al. 2024. Mar Drugs. 22: PMID: 39330272

The preferred Chr-A antibody is Chr-A Antibody (C-12): sc-393941.