Chr-A Antibody (LK2H10): sc-47714

Chr-A Antibody (LK2H10) is a mouse monoclonal IgG1 antibody that detects Chromogranin A (Chr-A) of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Chr-A antibody (LK2H10) is available in a non-conjugated form, specifically designed for versatile applications in research. Chromogranin A is an acidic glycoprotein primarily located within secretory granules of neuroendocrine and endocrine tissues, playing a crucial role in hormone and neuropeptide storage and release. Chr-A (LK2H10) monoclonal antibody helps detect elevated Chr-A levels, which serve as biomarkers for neuroendocrine tumor diagnosis and prognosis. Chromogranin A is also the precursor to several biologically active peptides, including pancreastatin, which inhibits insulin secretion and regulates gastric acid secretion. Understanding Chromogranin A function and regulation helps elucidate neuroendocrine signaling mechanisms and their implications in various pathologies. Through interactions with other secretory process proteins, Chr-A maintains neuroendocrine function homeostasis, making Chr-A (LK2H10) antibody a valuable research tool for studying these complex biological systems.

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Chr-A Antibody (LK2H10) References:

1. Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells.  |  Hosaka, M., et al. 2002. Mol Biol Cell. 13: 3388-99. PMID: 12388744
2. Immunocytochemical localization of secretogranin III in the anterior lobe of male rat pituitary glands.  |  Sakai, Y., et al. 2003. J Histochem Cytochem. 51: 227-38. PMID: 12533531
3. Immunolocalization of secretogranin II, chromogranin A, and chromogranin B in differentiating human neuroblastoma cells.  |  Giudici, AM., et al. 1992. Eur J Cell Biol. 58: 383-9. PMID: 1425774
4. Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A.  |  Hosaka, M., et al. 2004. J Biol Chem. 279: 3627-34. PMID: 14597614
5. Interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting within secretory granules.  |  Hosaka, M., et al. 2005. J Cell Sci. 118: 4785-95. PMID: 16219686
6. Chrysomycin A Attenuates Neuroinflammation by Down-Regulating NLRP3/Cleaved Caspase-1 Signaling Pathway in LPS-Stimulated Mice and BV2 Cells.  |  Liu, M., et al. 2021. Int J Mol Sci. 22: PMID: 34202695
7. Chrysomycin A Regulates Proliferation and Apoptosis of Neuroglioma Cells via the Akt/GSK-3β Signaling Pathway In Vivo and In Vitro.  |  Liu, DN., et al. 2023. Mar Drugs. 21: PMID: 37367654
8. Measurements of chromogranin A, chromogranin B (secretogranin I), chromogranin C (secretogranin II) and pancreastatin in plasma and urine from patients with carcinoid tumours and endocrine pancreatic tumours.  |  Stridsberg, M., et al. 1995. J Endocrinol. 144: 49-59. PMID: 7891024
9. Immunohistochemical demonstration of chromogranin A, chromogranin B, and secretogranin II in extra-adrenal paragangliomas.  |  Schmid, KW., et al. 1994. Mod Pathol. 7: 347-53. PMID: 8058707
10. Current status on chromogranin A and pancreastatin.  |  Robberecht, P., et al. 1993. Acta Gastroenterol Belg. 56: 261-3. PMID: 8266767
11. Chromogranin A, secretogranin II and vasoactive intestinal peptide in phaeochromocytomas and ganglioneuromas.  |  Schmid, KW., et al. 1993. Histopathology. 22: 527-33. PMID: 8354485
12. Histamine induces a gene-specific synthesis regulation of secretogranin II but not of chromogranin A and B in chromaffin cells in a calcium-dependent manner.  |  Bauer, JW., et al. 1993. J Biol Chem. 268: 1586-9. PMID: 8420933

The preferred Chr-A antibody is Chr-A Antibody (C-12): sc-393941.