Molecular structure of CHPG, CAS Number: 170846-74-9
CHPG (CAS 170846-74-9)
Alternate Names:
α-Amino-2-chloro-5-hydroxybenzeneacetic acid; (RS)-2-Chloro-5-hydroxyphenylglycine
Application:
CHPG is a selective mGluR-5 agonist
CAS Number:
170846-74-9
Molecular Weight:
201.61
Molecular Formula:
C8H8NO3Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CHPG is a selective metabotropic glutamate receptor agonist, mGluR-5. CHPG is inactive at mGluR-1a which is expressed in CHO cells. CHPG is a derivative of an amino acid, known for its versatility in facilitating the study of diverse biochemical and physiological processes.
CHPG (CAS 170846-74-9) References
- Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus. | Salt, TE., et al. 1999. Br J Pharmacol. 127: 1057-9. PMID: 10455248
- Potentiation of NMDA and AMPA responses by the specific mGluR5 agonist CHPG in spinal cord motoneurons. | Ugolini, A., et al. 1999. Neuropharmacology. 38: 1569-76. PMID: 10530818
- DHPG-induced LTD in area CA1 of juvenile rat hippocampus; characterisation and sensitivity to novel mGlu receptor antagonists. | Fitzjohn, SM., et al. 1999. Neuropharmacology. 38: 1577-83. PMID: 10530819
- Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism. | O'Leary, DM., et al. 2000. Br J Pharmacol. 131: 1429-37. PMID: 11090117
- The mGlu5 receptor agonist CHPG stimulates striatal glutamate release: possible involvement of A2A receptors. | Pintor, A., et al. 2000. Neuroreport. 11: 3611-4. PMID: 11095529
- Activation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedges. | Attucci, S., et al. 2001. Br J Pharmacol. 132: 799-806. PMID: 11181420
- Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons. | Pisani, A., et al. 2001. Neuroscience. 106: 579-87. PMID: 11591458
- Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischemia. | Bao, WL., et al. 2001. Brain Res. 922: 173-9. PMID: 11743947
- Metabotropic glutamate receptor 5 (mGluR5)-mediated phosphoinositide hydrolysis and NMDA-potentiating effects are blunted in the striatum of aged rats: a possible additional mechanism in striatal senescence. | Domenici, MR., et al. 2003. Eur J Neurosci. 17: 2047-55. PMID: 12786971
- Attenuation of ketamine-evoked behavioral responses by mGluR5 positive modulators in mice. | Chan, MH., et al. 2008. Psychopharmacology (Berl). 198: 141-8. PMID: 18311557
- Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity. | Byrnes, KR., et al. 2009. Glia. 57: 550-60. PMID: 18816644
- Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents. | Byrnes, KR., et al. 2009. Ann Neurol. 66: 63-74. PMID: 19670441
- Nitrative stress in cerebral endothelium is mediated by mGluR5 in hyperhomocysteinemia. | Mayo, JN., et al. 2012. J Cereb Blood Flow Metab. 32: 825-34. PMID: 22186670
- Functional role of striatal A2A, D2, and mGlu5 receptor interactions in regulating striatopallidal GABA neuronal transmission. | Beggiato, S., et al. 2016. J Neurochem. 138: 254-64. PMID: 27127992
- (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. | Doherty, AJ., et al. 1997. Neuropharmacology. 36: 265-7. PMID: 9144665
Activator of:
mGluR-1, and mGluR-5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CHPG, 10 mg | sc-205931 | 10 mg | $113.00 | |||
CHPG, 50 mg | sc-205931A | 50 mg | $478.00 |