Choriogonadotropin Holo c3 Antibody (INN-hCG-45): sc-57060

Choriogonadotropin Holo c3 Antibody (INN-hCG-45) is a mouse monoclonal IgG1 antibody that detects the c3 epitope on holo Choriogonadotropin of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Choriogonadotropin Holo c3 antibody (INN-hCG-45) is available in a non-conjugated form, providing researchers with a versatile tool for studying this critical hormone. Choriogonadotropin, produced by the placenta during the first trimester of pregnancy, plays a vital role in maintaining pregnancy by stimulating the ovaries to produce essential steroids such as estrogen and progesterone. This hormone exists as a heterodimer composed of a unique β chain and an α chain that is common to all gonadotropins, with the unique β chain providing biological specificity to choriogonadotropin, luteinizing hormone, and follicle-stimulating hormone. The α subunit is encoded by a gene located on human chromosome 6, while the β subunit is mapped to chromosome 19. The proper functioning of choriogonadotropin is crucial, as choriogonadotropin not only supports the maintenance of pregnancy but also is a member of the cystine knot growth-factor superfamily, characterized by a distinct arrangement of six cysteine residues. This structural feature is essential for the hormone′s stability and activity, as the correct conformation of the cystine knot is necessary for secretion and dimerization, although the biological activity itself is independent of this conformation.

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Choriogonadotropin Holo c3 Antibody (INN-hCG-45) References:

1. Chromosome assignment of genes encoding the alpha and beta subunits of glycoprotein hormones in man and mouse.  |  Naylor, SL., et al. 1983. Somatic Cell Genet. 9: 757-70. PMID: 6581542
2. The cystine-knot growth-factor superfamily.  |  Sun, PD. and Davies, DR. 1995. Annu Rev Biophys Biomol Struct. 24: 269-91. PMID: 7663117
3. Mutagenesis of cysteine residues in the human gonadotropin alpha subunit. Roles of individual disulfide bonds in secretion, assembly, and biologic activity.  |  Furuhashi, M., et al. 1994. J Biol Chem. 269: 25543-8. PMID: 7929256
4. Crystal structure of human chorionic gonadotropin.  |  Lapthorn, AJ., et al. 1994. Nature. 369: 455-61. PMID: 8202136
5. Disulfide bonds 7-31 and 59-87 of the alpha-subunit play a different role in assembly of human chorionic gonadotropin and lutropin.  |  Furuhashi, M., et al. 1996. Endocrinology. 137: 4196-200. PMID: 8828477
6. Cystine knot of the gonadotropin alpha subunit is critical for intracellular behavior but not for in vitro biological activity.  |  Sato, A., et al. 1997. J Biol Chem. 272: 18098-103. PMID: 9218442
7. Regulation of prostaglandin F2alpha-receptor mRNA in human granulosa-luteal cells by human chorionic gonadotrophin and prostaglandin F2alpha.  |  Väänänen, JE., et al. 1998. Endocrine. 8: 261-7. PMID: 9741831
8. Structural and molecular studies of human chorionic gonadotropin and its receptor.  |  Lustbader, JW., et al. 1998. Recent Prog Horm Res. 53: 395-424; discussion 424-5. PMID: 9769716

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Choriogonadotropin Holo c3 Antibody (INN-hCG-45) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Choriogonadotropin Holo c3 Antibody (INN-hCG-45) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Choriogonadotropin Holo c3 Antibody (INN-hCG-45) Specifications

Alternate Product Name: Choriogonadotropin Holo c3

Product Clone Name: INN-hCG-45

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Choriogonadotropin

Epitope Species: human

Product Reactivity/Detection: the c3 epitope on holo Choriogonadotropin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Choriogonadotropin Holo c3 Antibody (INN-hCG-45): N/A