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Cholesteryl oleate (CAS 303-43-5)

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Alternate Names:
Oleic acid cholesteryl ester; 5-Cholesten-3β-ol 3-oleate; Cholesteryl cis-9-octadecenoate
Application:
Cholesteryl oleate is an esterified form cholesterol found in plasma
CAS Number:
303-43-5
Purity:
≥98%
Molecular Weight:
651.10
Molecular Formula:
C45H78O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cholesteryl oleate is an esterified form cholesterol found in plasma. The liver is a primary source of cholesteryl oleate that enriches the LDL particles when released into plasma. The secretion of lipoproteins enriched with cholesteryl oleate has close correlation with the pathogenesis of coronary artery atherosclerosis.


Cholesteryl oleate (CAS 303-43-5) References

  1. Lower absorption of cholesteryl oleate in rats supplemented with Areca catechu L. extract.  |  Jeon, SM., et al. 2000. Ann Nutr Metab. 44: 170-6. PMID: 11111132
  2. Study of the miscibility of cholesteryl oleate in a matrix of ceramide, cholesterol and fatty acid.  |  Souza, SL., et al. 2011. Chem Phys Lipids. 164: 664-71. PMID: 21756886
  3. LDL particle core enrichment in cholesteryl oleate increases proteoglycan binding and promotes atherosclerosis.  |  Melchior, JT., et al. 2013. J Lipid Res. 54: 2495-503. PMID: 23804810
  4. Binary phase behavior of cholesteryl oleate with cholesteryl linoleate.  |  Dorset, DL. 1990. Biochim Biophys Acta. 1046: 57-63. PMID: 2397245
  5. Cholesteryl ester species differently elevate plasma cholesterol in hamsters.  |  Jiao, R., et al. 2013. J Agric Food Chem. 61: 11041-7. PMID: 24151965
  6. Competitive Solubilization of Cholesterol/Cholesteryl Oleate and Seven Species of Sterol/Stanol in Model Intestinal Solution System.  |  Matsuoka, K., et al. 2015. J Oleo Sci. 64: 783-91. PMID: 26136176
  7. Integration of lipidomics and transcriptomics unravels aberrant lipid metabolism and defines cholesteryl oleate as potential biomarker of prostate cancer.  |  Li, J., et al. 2016. Sci Rep. 6: 20984. PMID: 26865432
  8. Cholesteryl oleate-loaded cationic solid lipid nanoparticles as carriers for efficient gene-silencing therapy.  |  Suñé-Pou, M., et al. 2018. Int J Nanomedicine. 13: 3223-3233. PMID: 29881274
  9. Drug-Loaded Nanocarriers Composed of Cholesteryl Oleate Crystal Cores and Multiple-Nanosheet Shells of γ-Cyclodextrin Inclusion Complex Crystals.  |  Ishimoto, A., et al. 2022. Langmuir. 38: 10454-10464. PMID: 35976036
  10. Orientational order of cholesteryl oleate in low-density lipoprotein observed by 2H-NMR.  |  Treleaven, WD., et al. 1986. Biochim Biophys Acta. 877: 198-210. PMID: 3718998
  11. Lipoprotein lipase hydrolysis of trioleoylglycerol in a phospholipid interface. Effect of cholesteryl oleate on catalysis.  |  Demel, RA. and Jackson, RL. 1985. J Biol Chem. 260: 9589-92. PMID: 4019488
  12. Solubilization of triolein and cholesteryl oleate in egg phosphatidylcholine vesicles.  |  Hamilton, JA., et al. 1983. J Biol Chem. 258: 12821-6. PMID: 6685124
  13. Cholesteryl ester transfer from phospholipid vesicles to human density lipoproteins.  |  Young, PM. and Brecher, P. 1981. J Lipid Res. 22: 944-54. PMID: 7276753
  14. Effects of cholesterol and cholesteryl oleate on lipolysis and liver uptake of triglyceride/phosphatidylcholine emulsions in rats.  |  Handa, T., et al. 1994. Pharm Res. 11: 1283-7. PMID: 7816757
  15. Hepatic origin of cholesteryl oleate in coronary artery atherosclerosis in African green monkeys. Enrichment by dietary monounsaturated fat.  |  Rudel, LL., et al. 1997. J Clin Invest. 100: 74-83. PMID: 9202059

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cholesteryl oleate, 100 mg

sc-207429
100 mg
$136.00

Cholesteryl oleate, 250 mg

sc-207429A
250 mg
$257.00