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Cholesteryl linoleate (CAS 604-33-1)

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Alternate Names:
3β-Hydroxy-5-cholestene 3-linoleate
Application:
Cholesteryl linoleate is a major cholesterol ester found associated with the neutral core of low density lipoprotein
CAS Number:
604-33-1
Molecular Weight:
649.08
Molecular Formula:
C45H76O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cholesteryl linoleate functions as a substrate in lipid metabolism studies. It is involved in the biosynthesis of cholesterol esters and plays a role in the regulation of cellular cholesterol levels. Cholesteryl linoleate is also used as a model compound to investigate the enzymatic hydrolysis of cholesteryl esters by various enzymes. Its mechanism of action involves its incorporation into cellular membranes, where it can be targeted by specific enzymes for hydrolysis. Cholesteryl Linoleate is particularly useful for studying the mechanisms of cholesterol ester metabolism and the regulation of cellular lipid homeostasis. In experimental applications, cholesteryl linoleate useful in investigating the molecular pathways involved in lipid metabolism and cellular cholesterol regulation.


Cholesteryl linoleate (CAS 604-33-1) References

  1. Endovascular needle injection of cholesteryl linoleate into the arterial wall produces complex vascular lesions identifiable by intravascular ultrasound: early development in a porcine model of vulnerable plaque.  |  Granada, JF., et al. 2005. Coron Artery Dis. 16: 217-24. PMID: 15915073
  2. Cellular damage in mouse peritoneal macrophages exposed to cholesteryl linoleate.  |  Reid, VC., et al. 1992. Atherosclerosis. 92: 251-60. PMID: 1632853
  3. The reduction of cholesteryl linoleate in lipoproteins: an index of clinical severity in beta-thalassemia/Hb E.  |  Luechapudiporn, R., et al. 2006. Clin Chem Lab Med. 44: 574-81. PMID: 16681427
  4. Lipids including cholesteryl linoleate and cholesteryl arachidonate contribute to the inherent antibacterial activity of human nasal fluid.  |  Do, TQ., et al. 2008. J Immunol. 181: 4177-87. PMID: 18768875
  5. Modification of composition of a nanoemulsion with different cholesteryl ester molecular species: effects on stability, peroxidation, and cell uptake.  |  Almeida, CP., et al. 2010. Int J Nanomedicine. 5: 679-86. PMID: 20957219
  6. Binary phase behavior of cholesteryl oleate with cholesteryl linoleate.  |  Dorset, DL. 1990. Biochim Biophys Acta. 1046: 57-63. PMID: 2397245
  7. Cholesteryl ester species differently elevate plasma cholesterol in hamsters.  |  Jiao, R., et al. 2013. J Agric Food Chem. 61: 11041-7. PMID: 24151965
  8. Kinetics of lipid radical formation in lipoproteins from β-thalassemia: Implication of cholesteryl esters and α-tocopherol.  |  Lerksaipheng, P., et al. 2022. Biomed Pharmacother. 154: 113624. PMID: 36057220
  9. Properties of cholesteryl esters in pure and mixed monolayers.  |  Kwong, CN., et al. 1971. J Lipid Res. 12: 31-5. PMID: 5542702
  10. Oxidation products of cholesteryl linoleate are resistant to hydrolysis in macrophages, form complexes with proteins, and are present in human atherosclerotic lesions.  |  Hoppe, G., et al. 1997. J Lipid Res. 38: 1347-60. PMID: 9254061
  11. Separation and characterization of cholesteryl oxo- and hydroxy-linoleate isolated from human atherosclerotic plaque.  |  Suarna, C., et al. 1997. Free Radic Res. 27: 397-408. PMID: 9416468
  12. Cholesteryl ester hydroperoxide formation in myoglobin-catalyzed low density lipoprotein oxidation: concerted antioxidant activity of caffeic and p-coumaric acids with ascorbate.  |  Vieira, O., et al. 1998. Biochem Pharmacol. 55: 333-40. PMID: 9484800

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cholesteryl linoleate, 100 mg

sc-214699
100 mg
$82.00

Cholesteryl linoleate, 250 mg

sc-214699A
250 mg
$158.00