(−)-Cholesterol sulfo-NHS succinate

(−)-Cholesterol sulfo-NHS succinate is a chemical derivative of cholesterol, designed to introduce sulfonyl groups into biomolecules in a highly selective and efficient manner. This derivative leverages the N-hydroxysuccinimide (NHS) ester moiety to facilitate the formation of stable sulfonamide bonds with primary amines at physiological pH, enhancing the hydrophilicity and modifying the surface characteristics of lipid-based assemblies. The incorporation of this compound into lipid membranes or particles is for studying membrane dynamics, lipid-protein interactions, and the assembly of lipid nanoparticles. Its role in research extends to the functionalization of liposomes and other nanocarriers, where it improves the targeting and delivery efficiency of these systems. By altering the physicochemical properties of lipids, (−)-Cholesterol sulfo-NHS succinate serves as useful in the development and characterization of lipid-based delivery systems, contributing to our understanding of cellular processes and the design of novel nanotechnologies.