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Chlortetracycline hydrochloride (CAS 64-72-2)

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Alternate Names:
Aureomycin HCI; Auxeomycin; Isphamycin
Application:
Chlortetracycline hydrochloride is a specific and potent calcium ionophore antibiotic
CAS Number:
64-72-2
Purity:
≥80%
Molecular Weight:
515.34
Molecular Formula:
C22H23ClN2O8•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Chlortetracycline Hydrochloride is a specific and potent calcium ionophore antibiotic. The compound may act to inhibit binding of aminoacyl-tRNA to ribosomes. In endoplasmic reticulum studies Chortetracycline has been used as a fluorescent dye to analyze calcium changes during apotosis, and in other processes. Chlortetracycline may act to block platelet secretion and can affect 17beta-estradiol (E2) synthesis in H295R cells. Kupffer cell studies have shown that Chlortetracycline can inhibit secretion of TNF alpha. We offer the Chlortetracycline Hydrochloride form.


Chlortetracycline hydrochloride (CAS 64-72-2) References

  1. Effects of temperature on calcium-sensitive fluorescent probes.  |  Oliver, AE., et al. 2000. Biophys J. 78: 2116-26. PMID: 10733989
  2. Chlortetracycline modulates acute phase response of ex vivo perfused pig livers, and inhibits TNF-alpha secretion by isolated Kupffer cells.  |  Akunda, JK., et al. 2001. Comp Immunol Microbiol Infect Dis. 24: 81-9. PMID: 11247048
  3. Flow cytometric evaluation of sperm parameters in relation to fertility potential.  |  Gillan, L., et al. 2005. Theriogenology. 63: 445-57. PMID: 15626410
  4. Analysis of calcium changes in endoplasmic reticulum during apoptosis by the fluorescent indicator chlortetracycline.  |  Cerella, C., et al. 2007. Ann N Y Acad Sci. 1099: 490-3. PMID: 17446492
  5. Effects of sulfathiazole, oxytetracycline and chlortetracycline on steroidogenesis in the human adrenocarcinoma (H295R) cell line and freshwater fish Oryzias latipes.  |  Ji, K., et al. 2010. J Hazard Mater. 182: 494-502. PMID: 20630653
  6. Codon-anticodon interaction at the ribosomal P (peptidyl-tRNA)site.  |  Wurmbach, P. and Nierhaus, KH. 1979. Proc Natl Acad Sci U S A. 76: 2143-7. PMID: 221915
  7. Photocatalytic degradation of chlortetracycline hydrochloride in marine aquaculture wastewater under visible light irradiation with CuO/ZnO.  |  Liu, J., et al. 2019. Water Sci Technol. 80: 1249-1256. PMID: 31850876
  8. Detection of Chlortetracycline Hydrochloride in Milk with a Solid SERS Substrate Based on Self-assembled Gold Nanobipyramids.  |  Li, N., et al. 2020. Anal Sci. 36: 935-940. PMID: 32009022
  9. Nitrogen-doped carbon dots from rhizobium as fluorescence probes for chlortetracycline hydrochloride.  |  Zhang, W., et al. 2020. Nanotechnology. 31: 445501. PMID: 32688347
  10. Chlortetracycline hydrochloride removal by different biochar/Fe composites: A comparative study.  |  Zhao, N., et al. 2021. J Hazard Mater. 403: 123889. PMID: 33264955
  11. Degradation of chlortetracycline hydrochloride by peroxymonosulfate activation on natural manganese sand through response surface methodology.  |  He, B., et al. 2022. Environ Sci Pollut Res Int. 29: 82584-82599. PMID: 35752673
  12. Inhibition of thrombin-induced secretion from platelets by chlortetracycline and its analogs.  |  Mürer, EH. and Siojo, E. 1982. Thromb Haemost. 47: 62-5. PMID: 6803382
  13. Characterization of chlortetracycline (aureomycin) as a calcium ionophore.  |  White, JR. and Pearce, FL. 1982. Biochemistry. 21: 6309-12. PMID: 7150561

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Chlortetracycline hydrochloride, 1 g

sc-202995
1 g
$20.00

Chlortetracycline hydrochloride, 5 g

sc-202995A
5 g
$52.00