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Chlorpromazine (CAS 50-53-3)

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Alternate Names:
Largactil; Thorazine; Contomin
Application:
Chlorpromazine is a anticholinergic, antidopaminergic and antihistaminic agent
CAS Number:
50-53-3
Purity:
97%
Molecular Weight:
318.86
Molecular Formula:
C17H19ClN2S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Chlorpromazine is a compound primarily known for its historical significance in various non-clinical research areas. In laboratory applications, Chlorpromazine is often used as a reference compound in studies examining the blockade of dopamine receptors, which contributes to our understanding of neurotransmitter systems in various animal models. It has been utilized in research related to the modulation of the dopaminergic system and to investigate the biochemical mechanisms underlying behavioral responses. Furthermore, Chlorpromazine is studied for its effects on various ion channels and cellular signaling pathways in different tissues, which aids in mapping out the complex interactions within the nervous system. In addition to its applications in neuroscience, the compound has also been used in biochemical assays as a tool to induce experimental models of oxidative stress, which is relevant in the study of cellular defense mechanisms against free radical damage.


Chlorpromazine (CAS 50-53-3) References

  1. Pharmacokinetics of chlorpromazine-induced miotic response in rabbits.  |  Kuehn, PB., et al. 1976. J Pharm Sci. 65: 1593-9. PMID: 1032895
  2. A relation between drug concentrations in brain and striatal homovanillic acid levels in chlorpromazine treated rats.  |  Sedvall, G. 1975. Life Sci. 16: 1145-55. PMID: 1134188
  3. A clinical evaluation of chlorpromazine therapy in chronic schizophrenics.  |  PACHTER, M. 1957. Am J Psychiatry. 113: 931. PMID: 13402990
  4. Effect of chlorpromazine on the cell metabolism.  |  YAMAMOTO, I., et al. 1957. Jpn J Pharmacol. 6: 138-46. PMID: 13480753
  5. Ion-pair complex-based solvent extraction combined with chemiluminescence determination of chlorpromazine hydrochloride with luminol in reverse micelles.  |  Shi, W., et al. 2004. J Pharm Biomed Anal. 36: 197-203. PMID: 15351066
  6. Chlorpromazine versus placebo for schizophrenia.  |  Adams, CE., et al. 2007. Cochrane Database Syst Rev. CD000284. PMID: 17443500
  7. The metabolites of chlorpromazine N-oxide in rat bile.  |  Jaworski, TJ., et al. 1991. Xenobiotica. 21: 1451-9. PMID: 1763519
  8. Chlorpromazine versus placebo for schizophrenia.  |  Adams, CE., et al. 2014. Cochrane Database Syst Rev. CD000284. PMID: 24395698
  9. Severe exacerbation of psychosis after sudden withdrawal of chlorpromazine in the treatment of methamphetamine-associated psychosis with aripiprazole and chlorpromazine: 2 case reports.  |  Wang, G., et al. 2014. J Addict Med. 8: 479-81. PMID: 25303986
  10. Kuhuang injection exerts a protective effect by activating PPAR-γ in an in vitro model of chlorpromazine-induced cholestatic liver injury constructed by tissue engineering.  |  Wu, Q., et al. 2022. Pharm Biol. 60: 1679-1689. PMID: 36063125
  11. Potentiation of the effects of chlorpromazine on exploration in the rat by a prior experience of the drug.  |  File, SE. 1973. Psychopharmacologia. 29: 357-63. PMID: 4707026
  12. Destruction of chlorpromazine during absorption in the rat in vivo and in vitro.  |  Curry, SH., et al. 1971. Br J Pharmacol. 42: 403-11. PMID: 5560899
  13. Effects of chlorpromazine on the disposition and beta-adrenergic blocking activity of propranolol in the dog.  |  Bai, SA. and Abramson, FP. 1984. J Pharmacokinet Biopharm. 12: 333-49. PMID: 6502474
  14. Problems in therapeutic blood monitoring of chlorpromazine.  |  Rivera-Calimlim, L. 1982. Ther Drug Monit. 4: 41-9. PMID: 7041337

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Chlorpromazine, 5 g

sc-357313
5 g
$61.00

Chlorpromazine, 25 g

sc-357313A
25 g
$110.00

Please let me know for how long this compound is stable in solution? and what temperature is the best for long term storage in solution? Thank you

Asked by: AmirMarvian
Thank you for your question. We do not have any stability data of this compound in solution. We recommend storing it at ambient temperature and dissolving it as solutions are needed.
Answered by: Technical Support Europe
Date published: 2020-10-16

I also need solubility information. Please help.

Asked by: fredy
Please see the previous answer above.
Answered by: Technical Support
Date published: 2019-01-26

Hello, I've recently bought this product but can't find solubility information for it. Where can I access this please? Many thanks

Asked by: HeatherBee
Thank you for your question. Chlorpromazine (CAS 50-53-3) sc-357313 is easily soluble in diethyl ether, insoluble in cold or hot water and very soluble in ethanol, and benzene. For further information please contact our technical service.
Answered by: SCBT Heidelberg Support
Date published: 2020-06-19
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Rated 5 out of 5 by from KazamaKazama, I. et al. (PubMed 26299819) reported that Chlorpromazine is likely to inhibit the process of thrombopoiesis persistently in megakaryocytes, as detected by the long-lasting decrease in the membrane capacitance and the irreversible suppression of the Kv1.3-channel currents. -SCBT Publication Review
Date published: 2015-01-14
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Chlorpromazine is rated 5.0 out of 5 by 1.
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