Chloroquine Antibody (HYB 317-01): sc-57681

Chloroquine Antibody (HYB 317-01) is a mouse monoclonal IgG2a antibody that detects Chloroquine protein of non-species reactive by enzyme-linked immunosorbent assay (ELISA). Anti-Chloroquine antibody (HYB 317-01) is available as a non-conjugated format. Chloroquine, a 4-aminoquinoline compound, plays a crucial role in malaria treatment and prevention by interfering with parasite′s ability to process heme. Inside red blood cells, Chloroquine becomes protonated and binds to heme, forming highly toxic FP-Chloroquine complex, which disrupts membrane function and leads to cell lysis, resulting in malaria parasite autodigestion. This mechanism proves vital not only for combating malaria but also for therapeutic effects in rheumatoid arthritis, where Chloroquine inhibits lymphocyte proliferation and modulates inflammatory pathways. Chloroquine has significant volume distribution, diffusing into adipose tissue, which influences pharmacokinetics and therapeutic efficacy. Common side effects include gastrointestinal disturbances, stomach ache, itchiness, headache, and blurred vision, highlighting patient monitoring importance during treatment.

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Chloroquine Antibody (HYB 317-01) References:

1. Chloroquine blood concentrations and molecular markers of chloroquine-resistant Plasmodium falciparum in febrile children in northern Ghana.  |  Ehrhardt, S., et al. 2003. Trans R Soc Trop Med Hyg. 97: 697-701. PMID: 16117966
2. Efficacy of artesunate plus chloroquine for uncomplicated malaria in children in Sao Tome and Principe: a double-blind, randomized, controlled trial.  |  Gil, VS., et al. 2003. Trans R Soc Trop Med Hyg. 97: 703-6. PMID: 16117967
3. Research influence on antimalarial drug policy change in Tanzania: case study of replacing chloroquine with sulfadoxine-pyrimethamine as the first-line drug.  |  Mubyazi, GM. and Gonzalez-Block, MA. 2005. Malar J. 4: 51. PMID: 16242017
4. Ocular toxicity due to chloroquine and hydroxychloroquine: electrophysiological and visual function correlates.  |  Tzekov, R. 2005. Doc Ophthalmol. 110: 111-20. PMID: 16249962
5. Low-dose quinine for treatment of chloroquine-resistant falciparum malaria in Sudanese pregnant women.  |  Adam, I., et al. 2004. East Mediterr Health J. 10: 554-9. PMID: 16335646
6. Unexpected skin reaction induced by radiotherapy after chloroquine use.  |  Rustogi, A., et al. 2006. Lancet Oncol. 7: 608-9. PMID: 16814214
7. Chloroquine resistance reversal agents as promising antimalarial drugs.  |  Henry, M., et al. 2006. Curr Drug Targets. 7: 935-48. PMID: 16918322
8. Risks and benefits of chloroquine use in anticancer strategies.  |  Savarino, A., et al. 2006. Lancet Oncol. 7: 792-3. PMID: 17012039
9. Malaria. Chloroquine makes a comeback.  |  Vogel, G. 2006. Science. 314: 904. PMID: 17095662

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Chloroquine Antibody (HYB 317-01) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Chloroquine Antibody (HYB 317-01) Specifications

Alternate Product Name: Chloroquine

Product Clone Name: HYB 317-01

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: Chloroquine

Epitope Species:

Product Reactivity/Detection: Chloroquine

Species Reactivity/Detection: NSR

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Chloroquine Antibody (HYB 317-01): N/A