Date published: 2026-5-15

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Chloromethanesulfonyl chloride (CAS 3518-65-8)

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Alternate Names:
Chloromesyl chloride
CAS Number:
3518-65-8
Purity:
≥95%
Molecular Weight:
149.00
Molecular Formula:
CH2Cl2O2S
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Chloromethanesulfonyl chloride is an organosulfur compound that serves a pivotal role in organic synthesis. Its functions span the realms of chlorination and reagent utilization, being instrumental in crafting a diverse range of valuable organic compounds. Furthermore, its significance resonates within pharmaceutical, dye, and chemical production industries, making it an indispensable contributor to the generation of essential products.


Chloromethanesulfonyl chloride (CAS 3518-65-8) References

  1. Stereoselective ring expansion via bicyclooxonium ion. A novel approach to oxocanes.  |  Sakamoto, Y., et al. 2002. Org Lett. 4: 675-8. PMID: 11869099
  2. Access to enantiomerically pure intermediates for (-)-geosmin synthesis starting from (4aS,5S)-4,4a,5,6,7,8-hexahydro-5-hydroxy-4a-methylnaphthalen-2(3H)-one.  |  Fuhshuku, K. and Sugai, T. 2002. Biosci Biotechnol Biochem. 66: 2267-72. PMID: 12450148
  3. The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-beta-hydroxylase.  |  Adams, CM., et al. 2010. Bioorg Med Chem Lett. 20: 4324-7. PMID: 20615692
  4. Novel triacsin C analogs as potential antivirals against rotavirus infections.  |  Kim, Y., et al. 2012. Eur J Med Chem. 50: 311-8. PMID: 22365411
  5. Total synthesis of (-)-lycoposerramine-S.  |  Shimada, N., et al. 2012. Angew Chem Int Ed Engl. 51: 11824-6. PMID: 23070836
  6. Total synthesis of 6-deoxyerythronolide B via C-C bond-forming transfer hydrogenation.  |  Gao, X., et al. 2013. J Am Chem Soc. 135: 4223-6. PMID: 23464668
  7. Exploring the effect of bioisosteric replacement of carboxamide by a sulfonamide moiety on N-glycosidic torsions and molecular assembly: synthesis and X-ray crystallographic investigation of N-(β-D-glycosyl)sulfonamides as N-glycoprotein linkage region analogues.  |  Srivastava, A., et al. 2013. Chemistry. 19: 17720-32. PMID: 24327548
  8. Novel nitroimidazole alkylsulfonamides as hypoxic cell radiosensitisers.  |  Bonnet, M., et al. 2014. Bioorg Med Chem. 22: 2123-32. PMID: 24650701
  9. Imidazopyridine- and purine-thioacetamide derivatives: potent inhibitors of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1).  |  Chang, L., et al. 2014. J Med Chem. 57: 10080-100. PMID: 25372276
  10. Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase.  |  Grombein, CM., et al. 2015. Eur J Med Chem. 90: 788-96. PMID: 25528333
  11. Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments.  |  Haftchenary, S., et al. 2016. ACS Comb Sci. 18: 569-74. PMID: 27518324
  12. Small Molecule Antagonists of the Nuclear Androgen Receptor for the Treatment of Castration-Resistant Prostate Cancer.  |  Johnson, JK., et al. 2016. ACS Med Chem Lett. 7: 785-90. PMID: 27563404
  13. Halomethanesulfonic Acids-A New Class of Polar Disinfection Byproducts: Standard Synthesis, Occurrence, and Indirect Assessment of Mitigation Options.  |  Zahn, D., et al. 2019. Environ Sci Technol. 53: 8994-9002. PMID: 31298842
  14. Protocol for Stereoselective Construction of Highly Functionalized Dienyl Sulfonyl Fluoride Warheads.  |  Zhang, ZW., et al. 2020. J Org Chem. 85: 13721-13734. PMID: 32960604
  15. Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors.  |  Li, D., et al. 2021. ACS Med Chem Lett. 12: 1678-1688. PMID: 34795856

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Chloromethanesulfonyl chloride, 5 g

sc-234333
5 g
$94.00