Date published: 2026-1-23

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Chloroacetyl-L-tyrosine (CAS 1145-56-8)

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CAS Number:
1145-56-8
Molecular Weight:
257.67
Molecular Formula:
C11H12ClNO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Chloroacetyl-L-tyrosine is a compound that is utilized in biochemical research, particularly in the study of enzyme kinetics and mechanisms. The chloroacetyl group attached to the L-tyrosine amino acid serves as an electrophilic moiety, which can be used to modify nucleophilic sites on proteins and enzymes, thereby providing insights into active site geometries and amino acid reactivity. Researchers use chloroacetyl-L-tyrosine to synthesize peptides with specific modifications, which are then studied to understand protein-protein interactions and protein function. Additionally, this compound is of interest in the field of proteomics, where it can be employed as a chemical probe to label and identify proteins under various conditions. The L-tyrosine residue of chloroacetyl-L-tyrosine also enables investigations into the role of aromatic side chains in protein structure and ligand recognition.


Chloroacetyl-L-tyrosine (CAS 1145-56-8) References

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  2. Some enzymic properties of a partially purified aminoacylase obtained from a Polish variety of rapeseed (Brassica campestris L.).  |  OZAKI, K. and WETTER, LR. 1961. Can J Biochem Physiol. 39: 843-53. PMID: 13731830
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  5. Conformational changes in chymotrypsin detected with antibodies. I. Antibody response to diisopropylphosphoryl-chymotrypsin.  |  Gundlach, HG. 1970. Hoppe Seylers Z Physiol Chem. 351: 690-5. PMID: 4987601
  6. Induction of T-lymphocyte responses to a small molecular weight antigen. II. specific tolerance induced in azebenzenearsonate (ABA)-specific T cells in Guniea pigs by administration of low doses of an ABA conjugate of chloroacetyl tyrosine in incomplete Freund's adjuvant.  |  Bullock, WW., et al. 1975. J Exp Med. 142: 261-74. PMID: 806648
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Chloroacetyl-L-tyrosine, 25 g

sc-294004
25 g
$233.00

Chloroacetyl-L-tyrosine, 100 g

sc-294004A
100 g
$547.00