Chloro(2,2′:6′,2″-terpyridine)platinum(II) chloride dihydrate, also identified as [(terpyr)PtCl]Cl, is a complex of Pt and a terpyridine ligand and a DNA intercalating agent. The characteristic UV-Vis bands of the free [(terpyr)PtCl]Cl compound are modified upon addition to ct-DNA, allowing spectroscopic investigation of this interaction. [(terpyr)PtCl]Cl is demonstrated to retard the mobility of the supercoiled form of pHV14 plasmid in gel electrophoresis and to competitively inhibit the intercalative nucleic acid binding of the Ethidium bromide (sc-203735) dye.
1. Jennette, K.W., et al. 1974. Proc. Natl. Acad. Sci. U.S.A. 71: 3839-3843. PMID: 4530265
2. Messori, L., et al. 2005. Bioinorg Chem Appl. 239-253. PMID: 18365102
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