Molecular structure of Chloro(2,2′:6′,2″-terpyridine)platinum(II) chloride dihydrate, CAS Number: 151120-25-1
Chloro(2,2′:6′,2″-terpyridine)platinum(II) chloride dihydrate (CAS 151120-25-1)
Alternate Names:
Dichloro(2,2′:6′,2′′-terpyridine)platinum(II) dihydrate
Application:
Chloro(2,2′:6′,2″-terpyridine)platinum(II) chloride dihydrate is a spectroscopic tag for proteins and DNA intercalator
CAS Number:
151120-25-1
Purity:
≥98%
Molecular Weight:
535.28
Molecular Formula:
C15H11Cl2N3Pt•2H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Chloro(2,2′:6′,2″-terpyridine)platinum(II) chloride dihydrate, also identified as [(terpyr)PtCl]Cl, is a complex of Pt and a terpyridine ligand and a DNA intercalating agent. The characteristic UV-Vis bands of the free [(terpyr)PtCl]Cl compound are modified upon addition to ct-DNA, allowing spectroscopic investigation of this interaction. [(terpyr)PtCl]Cl is demonstrated to retard the mobility of the supercoiled form of pHV14 plasmid in gel electrophoresis and to competitively inhibit the intercalative nucleic acid binding of the Ethidium bromide (sc-203735) dye.
Chloro(2,2′:6′,2″-terpyridine)platinum(II) chloride dihydrate (CAS 151120-25-1) References
- Molecular recognition of metal complexes by DNA: a comparative study of the interactions of the parent complexes [PtCl(TERPY)]Cl and [AuCl(TERPY)]Cl2 with double stranded DNA. | Messori, L., et al. 2005. Bioinorg Chem Appl. 3: 239-53. PMID: 18365102
- Binding of Platinum(II) to Some Biologicaly Important Thiols. | Petrovic, BV., et al. 1999. Met Based Drugs. 6: 355-60. PMID: 18475912
- Electrostatic repulsion between the cations of (1-methyl-1H-imidazole-κN)(2,2':6',2''-terpyridine-κN,N',N'')platinum(II) perchlorate nitro-methane monosolvate prevents Pt⋯Pt inter-actions. | Akerman, M., et al. 2011. Acta Crystallogr Sect E Struct Rep Online. 67: m1075-6. PMID: 22090854
- Scanning electron microscope studies of human metaphase chromosomes. | Shemilt, LA., et al. 2014. Philos Trans A Math Phys Eng Sci. 372: 20130144. PMID: 24470422
- A DNA hybridization sensor based on catalytic response by platinum deposition. | Yasukawa, T., et al. 2015. Analyst. 140: 1014-8. PMID: 25607535
- Binuclear platinum (II)-terpyridine complexes. A new class of bifunctional DNA-intercalating agent. | McFadyen, WD., et al. 1986. Biochem J. 238: 757-63. PMID: 3800959
- Metallointercalation reagents. 2-hydroxyethanethiolato(2,2',2'-terpyridine)-platinum(II) monocation binds strongly to DNA by intercalation. | Jennette, KW., et al. 1974. Proc Natl Acad Sci U S A. 71: 3839-43. PMID: 4530265
- New routes for the synthesis of chloro (diethylenetriamine) platinum (II) chloride and chloro (2, 2′: 6′, 2 ″-terpyridine) platinum (II) chloride dihydrate | Annibale G, Brandolisio M, Pitteri B. 1995. Polyhedron. 14: 451-453.
- Crystal and Molecular Structure of the Yellow Form of Chloro (2, 2': 6', 2''-terpyridine) platinum (II) chloride dihydrate,[Pt (terpy) Cl] Cl· 2H_2O | ŞENGÜL A. 2004. Turkish Journal of Chemistry. 28: 667-672.
- Red and Orange Polymorphs of [Pt (terpy) Cl] Cl· 2H 2 O | Janzen D E, Mann K R. 2013. Journal of Chemical Crystallography. 43: 292-298.
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chloro(2,2′:6′,2″-terpyridine)platinum(II) chloride dihydrate, 500 mg | sc-211071 | 500 mg | $355.00 |