Molecular structure of Chloro-IB-MECA, CAS Number: 163042-96-4
Chloro-IB-MECA (CAS 163042-96-4)
Alternate Names:
Cl-IB-MECA; 2-Chloro-N6-(3-iodobenzyl)-adenosine-5′-N-methyluronamide
Application:
Chloro-IB-MECA is a selective Adenosine A3-R activator
CAS Number:
163042-96-4
Purity:
≥98%
Molecular Weight:
544.73
Molecular Formula:
C18H18ClIN6O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Chloro-IB-MECA is an A3 adenosine receptor agonist.
Chloro-IB-MECA (CAS 163042-96-4) References
- Effects of A(3) adenosine receptor activation and gene knock-out in ischemic-reperfused mouse heart. | Harrison, GJ., et al. 2002. Cardiovasc Res. 53: 147-55. PMID: 11744023
- An adenosine analogue, IB-MECA, down-regulates estrogen receptor alpha and suppresses human breast cancer cell proliferation. | Lu, J., et al. 2003. Cancer Res. 63: 6413-23. PMID: 14559831
- The role of intraspinal adenosine A1 receptors in sympathetic regulation. | Peng, SC., et al. 2004. Eur J Pharmacol. 492: 49-55. PMID: 15145705
- Characterization of adenosine receptors in the human bladder carcinoma T24 cell line. | Phelps, PT., et al. 2006. Eur J Pharmacol. 536: 28-37. PMID: 16581066
- Pharmacological targets revealed by myocardial postconditioning. | Burley, DS. and Baxter, GF. 2009. Curr Opin Pharmacol. 9: 177-88. PMID: 19109069
- Adenosine A2A receptor agonists and PDE inhibitors: a synergistic multitarget mechanism discovered through systematic combination screening in B-cell malignancies. | Rickles, RJ., et al. 2010. Blood. 116: 593-602. PMID: 20382846
- Postconditioning and protection from reperfusion injury: where do we stand? Position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology. | Ovize, M., et al. 2010. Cardiovasc Res. 87: 406-23. PMID: 20448097
- Adenosine A2A and beta-2 adrenergic receptor agonists: novel selective and synergistic multiple myeloma targets discovered through systematic combination screening. | Rickles, RJ., et al. 2012. Mol Cancer Ther. 11: 1432-42. PMID: 22474168
- Enhanced survival of lethally irradiated adenosine A3 receptor knockout mice. A role for hematopoietic growth factors? | Hofer, M., et al. 2015. Purinergic Signal. 11: 79-85. PMID: 25358454
- Fake Inhibitors: AMPK Activation Trumps Inhibition. | Langendorf, CG., et al. 2017. Cell Chem Biol. 24: 775-777. PMID: 28732195
- Activation of A1 and A2a adenosine receptors promotes neural progenitor cell proliferation. | Lv, J., et al. 2018. Brain Res. 1686: 65-71. PMID: 29476752
- A Novel Antagonistic CD73 Antibody for Inhibition of the Immunosuppressive Adenosine Pathway. | Wurm, M., et al. 2021. Mol Cancer Ther. 20: 2250-2261. PMID: 34482286
Inhibitor of:
Adenosine A3-R.Activator of:
Adenosine A3-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chloro-IB-MECA, 5 mg | sc-257229 | 5 mg | $615.00 |