Chloro-IB-MECA CAS: 163042-96-4
MF: C18H18ClIN6O4
MW: 544.73
A selective Adenosine A3-R activator.

Chloro-IB-MECA (CAS 163042-96-4)

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Alternate Names: Cl-IB-MECA; 2-Chloro-N6-(3-iodobenzyl)-adenosine-5′-N-methyluronamide
Application: Chloro-IB-MECA is a selective Adenosine A3-R activator
CAS Number: 163042-96-4
Purity: ≥98%
Molecular Weight: 544.73
Molecular Formula: C18H18ClIN6O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Chloro-IB-MECA is an Adenosine A3-R agonist with a Ki value of 0.33 nM. Chloro-IB-MECA displays 2500 and 1400-fold selectivity over Adenosine A1-R and Adenosine A2A-R, respectively. This explains selectivity over the Na+-independent adenosine transporter.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at room temperature
Melting Point :
207-208° C
Density :
~2.0 g/cm3 (Predicted)
Refractive Index :
n20D 1.81 (Predicted)
IC50 :
Adenosine A3-R: IC50 = 2.2 nM (human); Plasmodium falciparum: IC50 = 6.31 µM; Adenosine A2B-R: EC5050 ≥10 µM (mouse)
Ki Data :
Adenosine A3-R: Ki= 0.18 nM (mouse); Adenosine A3-R: Ki= 0.22 nM (human); Adenosine A3-R: Ki= 0.33 nM (rat); Adenosine A1-R: Ki= 35 nM (mouse); Adenosine A2A-R: Ki= 56 nM (rat)
pK Values :
pKa: 12.68 (Predicted), pKb: 0.11 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
3035850
MDL Number :
MFCD01861178
SMILES :
CNC(=O)[[email protected]@H]1[[email protected]]([[email protected]]([[email protected]@H](O1)N2C=NC3=C2N=C(N=C3NCC4=CC(=CC=C4)I)Cl)O)O

Download SDS (MSDS)

Certificate of Analysis

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