Chlorhexidine, Dihydrochloride CAS: 3697-42-5
MF: C22H30Cl2N10 2HCl
MW: 578.37
An anti-microbial agent that acts as an inhibitor of MMP-2 and MMP-9.

Chlorhexidine, Dihydrochloride (CAS 3697-42-5)

Chlorhexidine, Dihydrochloride | CAS 3697-42-5 is rated 5.0 out of 5 by 1.
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Application: Chlorhexidine, Dihydrochloride is an anti-microbial agent that acts as an inhibitor of MMP-2 and MMP-9
CAS Number: 3697-42-5
Purity: ≥95%
Molecular Weight: 578.37
Molecular Formula: C22H30Cl2N10 2HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Chlorhexidine, Dihydrochloride is an anti-microbial agent that acts as an inhibitor of MMP-2 and MMP-9 metalloproteinases. However, MMP-2 is more sensitive to chlorhexidine than MMP-9. Chlorhexidine dihydrochloride inhibits the collagenase activity of MMP-8 released by PMA-triggered polymorphonuclear leukocytes (PMNs) in a dose-dependent manner. Chlorhexidine dihydrochloride may possibly act through a cation-chelating mechanism.


References

Gendron, R., et al. 1999. Clin. Diagn. Lab. Immunol. 6, 437.

Physical State :
Solid
Solubility :
Soluble in DMSO, and methanol. Insoluble in water.
Storage :
Store at 4° C
Melting Point :
263-273° C
Boiling Point :
699.3° C at 760 mmHg (Predicted)
pK Values :
pKb: 11.85 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
XA5285000
PubChem CID :
62517
Merck Index :
14: 2091
MDL Number :
MFCD00068998
EC Number :
223-026-6
SMILES :
C1=CC(=CC=C1NC(=NC(=NCCCCCCN=C(N)N=C(N)NC2=CC=C(C=C2)Cl)N)N)Cl.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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Chlorhexidine, Dihydrochloride (CAS 3697-42-5)  Product Citations

See how others have used Chlorhexidine, Dihydrochloride (CAS 3697-42-5). Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 18378652  Lawrence, JR. et al. 2008. Appl. Environ. Microbiol. 74: 3541-3550.

PMID: # 869941  Gonzalez-Lama, Z. et al. 1977. Biochem Med. 17: 292-299.

PMID: # 1173318  Jensen, JE. et al. 1975. Acta Pharmacol Toxicol (Copenh). 36: 366-376.

PMID: # 5051634  Raizada, MK. et al. 1972. Arch Mikrobiol. 84: 119-128.

PMID: # 5793124  Husain, MM. et al. 1969. J. Gen. Microbiol. 56: 379-386.

PMID: # 13595630  BEEUWKES, H. et al. 1958. Antonie Van Leeuwenhoek. 24: 49-62.

Citations 1 to 6 of 6 total
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Rated 5 out of 5 by from Lawrence Lawrence, JR. et al. (PubMed 18378652) tested chlorhexidine, an antibacterial/fungal agent found in many personal care products, against several biofilm communities to determine its environmental impact on river microbial development. Toxicological testing indicated no detectable effects of chlorhexidine on cyanobacteria, algae, or protozoa. -SCBT Publication Review
Date published: 2015-06-30
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