Date published: 2026-5-28

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Chlorguanide Hydrochloride (CAS 637-32-1)

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Application:
Chlorguanide Hydrochloride is a synergistic inhibitor of plasmodial dihydrofolate reductase (DHFR)
CAS Number:
637-32-1
Molecular Weight:
290.19
Molecular Formula:
C11H16ClN5 HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Chlorguanide hydrochloride, a chemical compound with notable antimicrobial properties, has been a focal point in scientific research due to its intriguing mechanism of action. This compound exerts its effects primarily through interference with microbial metabolism, disrupting vital cellular processes. By targeting specific enzymatic pathways essential for microbial growth and reproduction, chlorguanide hydrochloride effectively inhibits the proliferation of various microorganisms. In research settings, chlorguanide hydrochloride has been extensively investigated for its antimicrobial efficacy against a diverse range of pathogens, including bacteria, fungi, and protozoa. Researchers have explored its mode of action at the molecular level, unraveling the complex biochemical mechanisms underlying its antimicrobial activity. Furthermore, chlorguanide hydrochloride has been utilized as a tool in studies focusing on microbial ecology and environmental microbiology. Its ability to selectively target microbial populations has facilitated investigations into microbial community dynamics and the ecological roles of specific microorganisms in various ecosystems. Moreover, chlorguanide hydrochloride′s antimicrobial properties have sparked interest in its potential applications such as in food preservation and industrial microbiology. By understanding its mechanisms of action and exploring its broad-spectrum activity, researchers aim to uncover novel strategies for combating microbial threats and advancing various fields of scientific inquiry.


Chlorguanide Hydrochloride (CAS 637-32-1) References

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  2. Comparison of antifibrillatory potency of certain antimalarial drugs with quinidine and procaine amide.  |  BURNO, F., et al. 1954. Circ Res. 2: 414-5. PMID: 13190621
  3. Current concepts of malaria; with a review of 510 admissions to a veterans hospital.  |  SCHWARTZ, R., et al. 1950. AMA Arch Intern Med. 86: 837-56. PMID: 14777198
  4. NEW and nonofficial remedies: chlorguanide hydrochloride.  |  . 1950. J Am Med Assoc. 143: 815. PMID: 15421840
  5. Gametocytocidal and sporontocidal effects of antimalarial drugs on malaria parasites. II. Action of the folic reductase inhibitors, chlorguanide, and pyrimethamine against Plasmodium cynomolgi.  |  Omar, MS., et al. 1974. Exp Parasitol. 36: 167-77. PMID: 4413531
  6. A reinvestigation of the structure of chlorguanide hydrochloride.  |  Ammon, HL. and Plastas, LA. 1973. J Med Chem. 16: 169-71. PMID: 4683114
  7. Synthesis and biological activity of (6aS)-10,11-dihydroxyaporphine, the optical antipode of apomorphine.  |  Saari, WS. and King, SW. 1973. J Med Chem. 16: 171-2. PMID: 4683115
  8. Treatment of American dermal leishmaniasis with cycloguanil pamoate.  |  Pena Chavarria, A., et al. 1968. Trans R Soc Trop Med Hyg. 62: 550-5. PMID: 5671542
  9. Stabilization of whole molecules of gastropodan haemocyanins by chlorhexidine.  |  Verschueren, LJ., et al. 1980. Int J Pept Protein Res. 16: 130-4. PMID: 7461895

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Chlorguanide Hydrochloride, 25 mg

sc-211068
25 mg
$227.00