Chlorfenapyr (CAS 122453-73-0)

Chlorfenapyr, a pyrrole pro-insecticide, undergoes metabolism in living organisms to produce CL 303268 via mixed function oxidases. Chlorfenapyr exhibits efficacy against a wide range of insects, including those that are susceptible or resistant to pyrethroid and organophosphate insecticides. This includes horn flies (H. irritans) as well as A. culicifacies and A. stephensi mosquitos, which carry malaria (LC50s = 2-2.39% suspension impregnated on paper). In terms of toxicity, chlorfenapyr is lethal to rats, with LD50 values of 441 mg/kg for males and 1,152 mg/kg for females. It has been utilized in formulations for termite control and agricultural applications targeting various insects. Chemically, chlorfenapyr belongs to the pyrrole class, specifically as 4-bromo-1H-pyrrole-3-carbonitrile substituted at positions 1, 2, and 5 by ethoxymethyl, p-chlorophenyl, and trifluoromethyl groups, respectively. It serves as a proinsecticide and a proacaricide, functioning as an organofluorine acaricide, organochlorine acaricide, organochlorine insecticide, and organofluorine insecticide. Additionally, it is classified as a member of monochlorobenzenes, a nitrile, a member of pyrroles, and a hemiaminal ether. Chlorfenapyr is derived from tralopyril.