Chloramphenicol palmitate (CAS 530-43-8)
QUICK LINKS
Chloramphenicol palmitate is an antibiotic compound that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. This binding prevents the formation of peptide bonds, leading to the inhibition of protein elongation. Chloramphenicol palmitate interferes with the peptidyl transferase activity of the ribosome, thereby blocking the synthesis of bacterial proteins. This disruption of protein synthesis ultimately results in the inhibition of bacterial growth and reproduction. By targeting the ribosome, chloramphenicol palmitate exerts its bacteriostatic effect, which may be useful for studying bacterial protein synthesis and the mechanisms of antibiotic resistance. Its mechanism of action at the molecular level provides insights into the fundamental processes of bacterial biology and can contribute to the development of new strategies for combating antibiotic resistance.
Chloramphenicol palmitate (CAS 530-43-8) References
- Characterization of chloramphenicol palmitate drug polymorphs by Raman mapping with multivariate image segmentation using a spatial directed agglomeration clustering method. | Lin, WQ., et al. 2006. Anal Chem. 78: 6003-11. PMID: 16944877
- Structural, electronic, thermodynamical and charge transfer properties of Chloramphenicol Palmitate using vibrational spectroscopy and DFT calculations. | Mishra, R., et al. 2013. Spectrochim Acta A Mol Biomol Spectrosc. 101: 335-42. PMID: 23123240
- Sustained-release microparticle dry powders of chloramphenicol palmitate or thiamphenicol palmitate prodrugs for lung delivery as aerosols. | Nurbaeti, SN., et al. 2019. Eur J Pharm Sci. 138: 105028. PMID: 31377132
- Unsafe 'crossover-use' of chloramphenicol in Uganda: importance of a One Health approach in antimicrobial resistance policy and regulatory action. | McCubbin, KD., et al. 2021. J Antibiot (Tokyo). 74: 417-420. PMID: 33742170
- Impact of gastrointestinal differences in veterinary species on the oral drug solubility, in vivo dissolution, and formulation of veterinary therapeutics. | Martinez, MN., et al. 2022. ADMET DMPK. 10: 1-25. PMID: 35360673
- Cyclodextrin Inclusion Complexes with Antibiotics and Antibacterial Agents as Drug-Delivery Systems-A Pharmaceutical Perspective. | Boczar, D. and Michalska, K. 2022. Pharmaceutics. 14: PMID: 35890285
- The Relevance of Crystal Forms in the Pharmaceutical Field: Sword of Damocles or Innovation Tools? | Braga, D., et al. 2022. Int J Mol Sci. 23: PMID: 36012275
- Effect of seed crystals on solid-state transformation of polymorphs of chloramphenicol palmitate during grinding. | Otsuka, M. and Kaneniwa, N. 1986. J Pharm Sci. 75: 506-11. PMID: 3735092
- Surface electric charge of the active and inactive polymorphs of chloramphenicol palmitate. | Kaliszan, R. 1986. J Pharm Sci. 75: 187-9. PMID: 3958931
- Effect of grinding on the transformations of polymorphs of chloramphenicol palmitate. | Kaneniwa, N. and Otsuka, M. 1985. Chem Pharm Bull (Tokyo). 33: 1660-8. PMID: 4042241
- Use of chloramphenicol palmitate in neonates. | Shankaran, S. and Kauffman, RE. 1984. J Pediatr. 105: 113-6. PMID: 6737126
- Bioavailability and pharmacokinetics of chloramphenicol palmitate in malnourished children. | Mahta, S., et al. 1981. Indian J Med Res. 74: 244-50. PMID: 6796509
- Pharmacokinetic and toxicological aspects of the medication of beef-type calves with an oral formulation of chloramphenicol palmitate. | Gassner, B. and Wuethrich, A. 1994. J Vet Pharmacol Ther. 17: 279-83. PMID: 7966547
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chloramphenicol palmitate, 250 mg | sc-252565 | 250 mg | $52.00 |