Molecular structure of Chlorambucil, CAS Number: 305-03-3
Chlorambucil (CAS 305-03-3)
See product citations (3)
Alternate Names:
Leukeran; Ambochlorin; Chlorbutin
Application:
Chlorambucil is a nitrogen bifunctional alkylating agent
CAS Number:
305-03-3
Purity:
≥98%
Molecular Weight:
304.21
Molecular Formula:
C14H19Cl2NO2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Chlorambucil is a nitrogen mustard bifunctional alkylating agent. Displays antineoplastic and immunosuppressant effect. Induces apoptosis in chronic lymphocytic leukemia cells.
Chlorambucil (CAS 305-03-3) References
- Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress. | Boldogh, I., et al. 2003. Toxicology. 193: 137-52. PMID: 14599773
- Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase. | Amrein, L., et al. 2007. J Pharmacol Exp Ther. 321: 848-55. PMID: 17351105
- Chlorambucil for patients with primary biliary cirrhosis. | Li, WX., et al. 2012. Cochrane Database Syst Rev. CD008714. PMID: 22972125
- Past, present and future role of chlorambucil in the treatment of chronic lymphocytic leukemia. | Goede, V., et al. 2015. Leuk Lymphoma. 56: 1585-92. PMID: 25219593
- Chlorambucil for the treatment of patients with chronic lymphocytic leukemia (CLL) - a systematic review and meta-analysis of randomized trials. | Vidal, L., et al. 2016. Leuk Lymphoma. 57: 2047-57. PMID: 26980554
- Ofatumumab plus chlorambucil as a first-line therapy in less fit patients with chronic lymphocytic leukemia: analysis of COMPLEMENT1 and other monoclonal antibodies association data. | Frustaci, AM., et al. 2016. Ther Adv Hematol. 7: 222-30. PMID: 27493712
- Tyrosine-Chlorambucil Conjugates Facilitate Cellular Uptake through L-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7. | Pocasap, P., et al. 2020. Int J Mol Sci. 21: PMID: 32244913
- Chlorambucil-Chitosan Nano-Conjugate: An Efficient Agent Against Breast Cancer Targeted Therapy. | Shayegh, A., et al. 2021. Curr Drug Deliv. 18: 721-728. PMID: 33109048
- Chlorambucil combination therapy in refractory serpiginous choroiditis: A cure? | Maleki, A., et al. 2021. Am J Ophthalmol Case Rep. 21: 101014. PMID: 33615036
- Chlorambucil induced pulmonary fibrosis: report of a case and review. | Carr, ME. 1986. Va Med. 113: 677-80. PMID: 3538689
- Malignancies induced by chlorambucil. | Palmer, RG. and Denman, AM. 1984. Cancer Treat Rev. 11: 121-9. PMID: 6388834
- DNA damage and mutagenesis induced by nitrogen mustards. | Povirk, LF. and Shuker, DE. 1994. Mutat Res. 318: 205-26. PMID: 7527485
- Chlorambucil-induced seizures. | Salloum, E., et al. 1997. Cancer. 79: 1009-13. PMID: 9041164
Inhibitor of:
4931408C20Rik, AL, B lymphocytes, C16orf62, CD22, CD8α, COL12A, FcRH4, Fcrls, FTF, FUS/TLS, Gight chain, GNL2, hnRNP H, Ig κ, Ig λ chain V4A, Ig λ light chain, IgA, IgA2, IgG Fab fragment, IgG light chain, IgG2, IgG2c, IgH-VJ558, IgHg, Igk-C, IgM, LOC441258, LOC441461, Might chain, Ncapg, NTH1, PRPF4, rat thymocytes, bone marrow, RBM10, SlfnL1, SNM1A, SNM1B, SPNR, SSB-4, and XRCC6BP1.Activator of:
4931417G12Rik, Ada, BCMP1, DNA Ligase IV, DNA2L, GEN1, GSTO1, RAD51AP2, Rad59, RAP80, RNF168, RNF169, and SMC1β.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chlorambucil, 250 mg | sc-204682 | 250 mg | $52.00 | |||
Chlorambucil, 1 g | sc-204682A | 1 g | $122.00 |