CHL1 Antibody (2H5): sc-293293

CHL1 Antibody (2H5) is a mouse monoclonal IgG2a kappa light chain antibody that detects CHL1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-CHL1 antibody (2H5) is available as the non-conjugated isotype antibody. CHL1, also known as Close Homolog of L1, is a crucial neural cell adhesion molecule that plays a significant role in neuronal development and growth. CHL1 is primarily located in the plasma membrane of neurons, where CHL1 facilitates cell-cell interactions and is essential for proper neuronal positioning and dendritic growth, particularly in pyramidal neurons of the developing neocortex. CHL1′s expression in a high-caudal to low-rostral gradient within the developing cortex is vital for guiding axon growth and ensuring accurate neural circuit formation. Through participation in signal transduction pathways, CHL1 influences cell migration and the overall architecture of the nervous system, making CHL1 a key player in neurodevelopmental processes.

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CHL1 Antibody (2H5) References:

1. CALL gene is haploinsufficient in a 3p- syndrome patient.  |  Angeloni, D., et al. 1999. Am J Med Genet. 86: 482-5. PMID: 10508992
2. An association between a missense polymorphism in the close homologue of L1 (CHL1, CALL) gene and schizophrenia.  |  Sakurai, K., et al. 2002. Mol Psychiatry. 7: 412-5. PMID: 11986985
3. Sister-chromatid cohesion mediated by the alternative RF-CCtf18/Dcc1/Ctf8, the helicase Chl1 and the polymerase-alpha-associated protein Ctf4 is essential for chromatid disjunction during meiosis II.  |  Petronczki, M., et al. 2004. J Cell Sci. 117: 3547-59. PMID: 15226378
4. Transcript profiling in the chl1-5 mutant of Arabidopsis reveals a role of the nitrate transporter NRT1.1 in the regulation of another nitrate transporter, NRT2.1.  |  Muños, S., et al. 2004. Plant Cell. 16: 2433-47. PMID: 15319483
5. Close homolog of L1 modulates area-specific neuronal positioning and dendrite orientation in the cerebral cortex.  |  Demyanenko, GP., et al. 2004. Neuron. 44: 423-37. PMID: 15504324
6. Impairment of sensorimotor gating in mice deficient in the cell adhesion molecule L1 or its close homologue, CHL1.  |  Irintchev, A., et al. 2004. Brain Res. 1029: 131-4. PMID: 15533325
7. Hereditary prostate cancer in Finland: fine-mapping validates 3p26 as a major predisposition locus.  |  Rökman, A., et al. 2005. Hum Genet. 116: 43-50. PMID: 15549392
8. L1 augments cell migration and tumor growth but not beta3 integrin expression in ovarian carcinomas.  |  Gast, D., et al. 2005. Int J Cancer. 115: 658-65. PMID: 15704102
9. CHL1 gene polymorphisms increase lung cancer susceptibility.  |  Tian, W., et al. 2018. Oncotarget. 9: 13545-13550. PMID: 29568376
10. Long noncoding RNA CHL1-AS1 promotes cell proliferation and migration by sponging miR-6076 to regulate CHL1 expression in endometrial cancer.  |  Shi, Y., et al. 2020. J Cell Biochem. 121: 2655-2663. PMID: 31736153
11. Exosomal miR-338-3p suppresses non-small-cell lung cancer cells metastasis by inhibiting CHL1 through the MAPK signaling pathway.  |  Tian, W., et al. 2021. Cell Death Dis. 12: 1030. PMID: 34718336
12. CHL1 inhibits cell proliferation, migration and invasion by regulating the NF‑κB signaling pathway in colorectal cancer.  |  Bao, M., et al. 2024. Exp Ther Med. 27: 165. PMID: 38476898