CHERP Antibody (SS5): sc-100650

CHERP Antibody (SS5) is a mouse monoclonal IgG2b kappa light chain antibody that detects CHERP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-CHERP antibody (SS5) is available as the non-conjugated isotype antibody. CHERP protein, also known as calcium homeostasis endoplasmic reticulum protein, SRA1, DAN16, or SCAF6, plays a crucial role in maintaining calcium homeostasis within cells, which is vital for proper functioning of voltage-gated ion channels that regulate muscle and nerve activity. This 916 amino acid protein is predominantly localized in the cytoplasm and endoplasmic reticulum, and expression spans various tissues, including pancreas, brain, lung, placenta, liver, kidney, heart, and skeletal muscle. CHERP is essential not only for calcium regulation but also for cell growth and proliferation, highlighting importance in cellular health and function. CHERP features a G-patch domain, an RPR domain, and a SURP motif, and exists in two isoforms due to alternative splicing, which may contribute to functional diversity and regulatory mechanisms in different cellular contexts.

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CHERP Antibody (SS5) References:

1. Cloning of human Ca2+ homoeostasis endoplasmic reticulum protein (CHERP): regulated expression of antisense cDNA depletes CHERP, inhibits intracellular Ca2+ mobilization and decreases cell proliferation.  |  Laplante, JM., et al. 2000. Biochem J. 348 Pt 1: 189-99. PMID: 10794731
2. Human T-cell lymphotropic virus type 1 p12(I) expression increases cytoplasmic calcium to enhance the activation of nuclear factor of activated T cells.  |  Ding, W., et al. 2002. J Virol. 76: 10374-82. PMID: 12239314
3. Antisense-mediated loss of calcium homoeostasis endoplasmic reticulum protein (CHERP; ERPROT213-21) impairs Ca2+ mobilization, nuclear factor of activated T-cells (NFAT) activation and cell proliferation in Jurkat T-lymphocytes.  |  O'Rourke, FA., et al. 2003. Biochem J. 373: 133-43. PMID: 12656674
4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.  |  Brandenberger, R., et al. 2004. Nat Biotechnol. 22: 707-16. PMID: 15146197
5. Ca2+ release by inositol 1,4,5-trisphosphate is blocked by the K(+)-channel blockers apamin and tetrapentylammonium ion, and a monoclonal antibody to a 63 kDa membrane protein: reversal of blockade by K+ ionophores nigericin and valinomycin and purification of the 63 kDa antibody-binding protein.  |  O'Rourke, F., et al. 1994. Biochem J. 300 (Pt 3): 673-83. PMID: 8010949

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CHERP Antibody (SS5) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-CHERP Antibody (SS5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CHERP Antibody (SS5) Specifications

Alternate Product Name: CHERP

Product Clone Name: SS5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 795-884

Epitope Target: CHERP

Epitope Species: human

Product Reactivity/Detection: CHERP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 50 µg IgG_2b kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for CHERP Antibody (SS5): N/A