CHD1L Antibody (2170C3a): sc-81065

CHD1L Antibody (2170C3a) is a mouse monoclonal IgG1 antibody that detects CHD1L protein of human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-CHD1L antibody (2170C3a) is available as the non-conjugated format. CHD1L protein, or Chromodomain helicase DNA-binding protein 1-like, consists of 897 amino acids and is encoded by the human gene CHD1L. CHD1L monoclonal antibody (2170C3a) recognizes a protein that plays a crucial role in chromatin remodeling, which is essential for regulating gene expression and maintaining genomic stability. CHD1L is part of the CHD family of proteins, which are ATP-dependent chromatin remodeling enzymes that combine chromodomains with SWI2/SNF2 ATPase/helicase motifs and DNA-binding capabilities. The chromodomain, a conserved protein region of approximately 40-50 amino acids, is integral to CHD1L′s function in chromatin manipulation, allowing for the dynamic regulation of DNA accessibility. The interaction of CHD1L with other chromatin-associated proteins is vital for its role in cellular processes such as DNA repair and transcriptional regulation, highlighting CHD1L′s importance in maintaining cellular homeostasis and responding to DNA damage. CHD1L (2170C3a) antibody is an invaluable tool for researchers studying the intricate mechanisms of chromatin dynamics and gene regulation in human cells.

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CHD1L Antibody (2170C3a) References:

1. CHD1 interacts with SSRP1 and depends on both its chromodomain and its ATPase/helicase-like domain for proper association with chromatin.  |  Kelley, DE., et al. 1999. Chromosoma. 108: 10-25. PMID: 10199952
2. CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins.  |  Tai, HH., et al. 2003. Biochem Biophys Res Commun. 308: 170-6. PMID: 12890497
3. Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains.  |  Sims, RJ., et al. 2005. J Biol Chem. 280: 41789-92. PMID: 16263726
4. Double chromodomains cooperate to recognize the methylated histone H3 tail.  |  Flanagan, JF., et al. 2005. Nature. 438: 1181-5. PMID: 16372014
5. Structural polymorphism of chromodomains in Chd1.  |  Okuda, M., et al. 2007. J Mol Biol. 365: 1047-62. PMID: 17098252
6. DNA-binding and chromatin localization properties of CHD1.  |  Stokes, DG. and Perry, RP. 1995. Mol Cell Biol. 15: 2745-53. PMID: 7739555
7. Characterization of the CHD family of proteins.  |  Woodage, T., et al. 1997. Proc Natl Acad Sci U S A. 94: 11472-7. PMID: 9326634

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CHD1L Antibody (2170C3a) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-CHD1L Antibody (2170C3a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CHD1L Antibody (2170C3a) Specifications

Alternate Product Name: CHD1L

Product Clone Name: 2170C3a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: CHD1L

Epitope Species: human

Product Reactivity/Detection: CHD1L

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for CHD1L Antibody (2170C3a): N/A