Molecular structure of Charybdotoxin, CAS Number: 95751-30-7
Charybdotoxin (CAS 95751-30-7)
See product citations (9)
Application:
Charybdotoxin is a potent and selective inhibitor of the large conductance Ca2+-activated K+ channels
CAS Number:
95751-30-7
Purity:
>98%
Molecular Weight:
4295.89
Molecular Formula:
C176H277N57O55S7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Charybdotoxin is a peptide found in the venom of the scorpion Leiurus quinquestriatus. High (BK) or intermediate (IK1) conductance calcium-activated and voltage-gated (Kv1.3) channel inhibitor. A potent and selective blocker of the large conductance Ca2+-activated K+, Slo channels in nanomolar concentrations as well as Kv1.2 (Kd = 14 nM) and Kv1.3 (Kd = 2.6 nM) channels. Present in GH3 anterior pituitary cells and primary bovine aortic smooth muscle cells.
Charybdotoxin (CAS 95751-30-7) References
- Leukotriene D4 (LTD4) activates charybdotoxin-sensitive and -insensitive K+ channels in ehrlich ascites tumor cells. | Hoffmann, EK. 1999. Pflugers Arch. 438: 263-8. PMID: 10398854
- Structural determinants of scorpion toxin affinity: the charybdotoxin (alpha-KTX) family of K(+)-channel blocking peptides. | Tenenholz, TC., et al. 2000. Rev Physiol Biochem Pharmacol. 140: 135-85. PMID: 10857399
- Charybdotoxin-sensitive small conductance K(Ca) channel activated by bradykinin and substance P in endothelial cells. | Sollini, M., et al. 2002. Br J Pharmacol. 136: 1201-9. PMID: 12163354
- Characterization of a charybdotoxin-sensitive intermediate conductance Ca2+-activated K+ channel in porcine coronary endothelium: relevance to EDHF. | Bychkov, R., et al. 2002. Br J Pharmacol. 137: 1346-54. PMID: 12466245
- Mechanism and energetics of charybdotoxin unbinding from a potassium channel from molecular dynamics simulations. | Chen, PC. and Kuyucak, S. 2009. Biophys J. 96: 2577-88. PMID: 19348743
- Charybdotoxin and margatoxin acting on the human voltage-gated potassium channel hKv1.3 and its H399N mutant: an experimental and computational comparison. | Nikouee, A., et al. 2012. J Phys Chem B. 116: 5132-40. PMID: 22490327
- Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor. | MacKinnon, R. and Miller, C. 1989. Science. 245: 1382-5. PMID: 2476850
- Charybdotoxin inhibits proliferation and interleukin 2 production in human peripheral blood lymphocytes. | Price, M., et al. 1989. Proc Natl Acad Sci U S A. 86: 10171-5. PMID: 2481312
- Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle. | Miller, C., et al. Nature. 313: 316-8. PMID: 2578618
- Trans-toxin ion-sensitivity of charybdotoxin-blocked potassium-channels reveals unbinding transitional states. | Moldenhauer, H., et al. 2019. Elife. 8: PMID: 31271355
- L-type Ca2+ channels and charybdotoxin-sensitive Ca2+-activated K+ channels are required for reduction of GABAergic activity induced by β2-adrenoceptor in the prefrontal cortex. | Deng, WK., et al. 2019. Mol Cell Neurosci. 101: 103410. PMID: 31644953
- Development of charybdotoxin Q18F variant as a selective peptide blocker of neuronal BK(α + β4) channel for the treatment of epileptic seizures. | Liu, X., et al. 2022. Protein Sci. 31: e4506. PMID: 36369672
- Charybdotoxin and its effects on potassium channels. | Garcia, ML., et al. 1995. Am J Physiol. 269: C1-10. PMID: 7543240
Inhibitor of:
CNG-1β, Ik1, KCNMB2, KCNMB3, KCNN2, KCNT1, KCNT2, Kir3, KVβ.2, KV1.3, KV9.3, LRRC26, MaxiK, MaxiKβ, SK3, Slo3, TALK-2, TWIK-2, TWIK-3, and Vmn1r157.Activator of:
KV2.2, and TRESK.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Charybdotoxin, 100 µg | sc-200979 | 100 µg | $401.00 |