Molecular structure of CHAPS, CAS Number: 75621-03-3
CHAPS (CAS 75621-03-3)
See product citations (4)
Alternate Names:
3-[(3-cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate; 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulphonate
Application:
CHAPS is a non-denaturing, zwitterionic detergent for membrane proteins
CAS Number:
75621-03-3
Purity:
≥99%
Molecular Weight:
614.87
Molecular Formula:
C32H58N2O7S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CHAPS is a non-denaturing, zwitterionic detergent derived from cholic acid. It is often used as a detergent in the solubilization and purification of membrane proteins for several advantageous reasons. CHAPS detergent is non-denaturing to membrane proteins, can solubilize proteins, disaggregates protein-protein interactions, and is electrically neutral. CHAPS is also useful in ion exchange chromatography and isoelectric focusing as it is zwitterionic and does not exhibit a net charge between pH 2 to 12. The critical micelle concentration of CHAPS is 6-10mM.
CHAPS (CAS 75621-03-3) References
- Characterization of solubilized opioid receptors: reconstitution and uncoupling of guanine nucleotide-sensitive agonist binding. | Ofri, D., et al. 1992. J Neurochem. 58: 628-35. PMID: 1309566
- Verification of surfactant CHAPS effect using AFM for making biomemory device consisting of recombinant azurin monolayer. | Lee, T., et al. 2010. Ultramicroscopy. 110: 712-7. PMID: 20206446
- The CHAPS, SIFTER, and TAPS-R as predictors of (C)AP skills and (C)APD. | Wilson, WJ., et al. 2011. J Speech Lang Hear Res. 54: 278-91. PMID: 20689023
- Behavior of the amphiphile CHAPS alone and in combination with the biopolymer inulin in water and isopropanol-water media. | Naskar, B., et al. 2011. Langmuir. 27: 9148-59. PMID: 21667919
- The complex interactions of Chs5p, the ChAPs, and the cargo Chs3p. | Rockenbauch, U., et al. 2012. Mol Biol Cell. 23: 4402-15. PMID: 23015758
- Comparative study of the interaction of CHAPS and Triton X-100 with the erythrocyte membrane. | Rodi, PM., et al. 2014. Biochim Biophys Acta. 1838: 859-66. PMID: 24239862
- CHAPS solubilization of a G-protein sensitive 5-HT1A receptor from bovine hippocampus. | Kline, T., et al. 1989. Life Sci. 45: 1997-2005. PMID: 2532283
- Solid phase extraction of the zwitterionic detergent chaps. | Hall, SW. and VandenBerg, SR. 1989. Prep Biochem. 19: 1-11. PMID: 2740288
- Crystal structure of the EnvZ periplasmic domain with CHAPS. | Hwang, E., et al. 2017. FEBS Lett. 591: 1419-1428. PMID: 28423182
- The Fluidity of Phosphocholine and Maltoside Micelles and the Effect of CHAPS. | Kieber, M., et al. 2019. Biophys J. 117: 2240. PMID: 31735325
- A comprehensive hospital agile preparedness (CHAPs) tool for pandemic preparedness, based on the COVID-19 experience. | Adelaja, I., et al. 2020. Future Healthc J. 7: 165-168. PMID: 32550286
- Quality and extent of implementation of a nurse-led care management intervention: care coordination for health promotion and activities in Parkinson's disease (CHAPS). | Connor, KI., et al. 2020. BMC Health Serv Res. 20: 732. PMID: 32778083
- Stakeholder perceptions of components of a Parkinson disease care management intervention, care coordination for health promotion and activities in Parkinson's disease (CHAPS). | Connor, KI., et al. 2020. BMC Neurol. 20: 437. PMID: 33267827
- Compression Hosiery to Avoid Post-Thrombotic Syndrome (CHAPS) Trial. | Lawton, R., et al. 2022. Eur J Vasc Endovasc Surg. 64: 431-432. PMID: 35961624
- A nondenaturing zwitterionic detergent for membrane biochemistry: design and synthesis. | Hjelmeland, LM. 1980. Proc Natl Acad Sci U S A. 77: 6368-70. PMID: 6935651
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CHAPS, 10 g | sc-29088 | 10 g | $219.00 | |||
CHAPS, 25 g | sc-29088A | 25 g | $420.00 | |||
CHAPS, 50 g | sc-29088B | 50 g | $663.00 |