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Chaetomellic acid A (CAS 148796-51-4)

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Application:
Chaetomellic acid A is a potent inhibitor of farnesyltransferase
CAS Number:
148796-51-4
Purity:
98%
Molecular Weight:
370.4
Molecular Formula:
C19H32O42Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Chaetomellic acid A is a potent inhibitor of histone deacetylase, operating through a specific binding interaction with the enzyme′s active site which prevents the removal of acetyl groups from histone proteins. This action results in elevated levels of histone acetylation, a modification known to relax the chromatin structure and enhance transcriptional activity. The altered chromatin state induced by chaetomellic acid A profoundly impacts gene expression profiles and orchestrates a variety of cellular processes, making it a agent for probing the dynamics of epigenetic modulation. By facilitating the sustained acetylation of histones, it offers a unique window into the molecular intricacies of chromatin remodeling and the epigenetic mechanisms that underpin gene regulation. Its utility extends to elucidating the pathways through which epigenetic factors influence cellular differentiation and maintenance, thereby contributing to the broader field of genomic studies and the exploration of chromatin′s role in cellular functionality and development.


Chaetomellic acid A (CAS 148796-51-4) References

  1. Inhibition of protein prenylation by metabolites of limonene.  |  Hardcastle, IR., et al. 1999. Biochem Pharmacol. 57: 801-9. PMID: 10075086
  2. Analysis of farnesyl transferase activity during hormone-induced maturation of Xenopus laevis oocytes.  |  Goalstone, ML. and Sadler, SE. 2000. J Exp Zool. 286: 193-203. PMID: 10617861
  3. Efficient syntheses, human and yeast farnesyl-protein transferase inhibitory activities of chaetomellic acids and analogues.  |  Singh, SB., et al. 2000. Bioorg Med Chem. 8: 571-80. PMID: 10732974
  4. Synthesis of Protein Farnesyltransferase and Protein Geranylgeranyltransferase Inhibitors: Rapid Access to Chaetomellic Acid A and Its Analogues.  |  Ratemi, ES., et al. 1996. J Org Chem. 61: 6296-6301. PMID: 11667470
  5. A facile synthesis of natural products chaetomellic acid A and 1,7(Z)- nonadecadiene-2,3-dicarboxylic acid.  |  Kar, A. and Argade, NP. 2002. J Org Chem. 67: 7131-4. PMID: 12354009
  6. Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase.  |  Mau, CJ., et al. 2003. Eur J Biochem. 270: 3939-45. PMID: 14511375
  7. Synthesis and biological activity of isopentenyl diphosphate analogues.  |  Scholte, AA., et al. 2004. Bioorg Med Chem. 12: 763-70. PMID: 14759736
  8. Synthesis of mono- and disaccharide analogs of moenomycin and lipid II for inhibition of transglycosylase activity of penicillin-binding protein 1b.  |  Garneau, S., et al. 2004. Bioorg Med Chem. 12: 6473-94. PMID: 15556765
  9. Inhibition of Ras/ERK1/2 signaling protects against postischemic renal injury.  |  Sabbatini, M., et al. 2006. Am J Physiol Renal Physiol. 290: F1408-15. PMID: 16434573
  10. Novel route to chaetomellic acid A and analogues: serendipitous discovery of a more competent FTase inhibitor.  |  Bellesia, F., et al. 2013. Bioorg Med Chem. 21: 348-58. PMID: 23182215
  11. Effect of angiotensin II and small GTPase Ras signaling pathway inhibition on early renal changes in a murine model of obstructive nephropathy.  |  Rodríguez-Peña, AB., et al. 2014. Biomed Res Int. 2014: 124902. PMID: 25101263
  12. The Effects of Long-Term Chaetomellic Acid A Administration on Renal Function and Oxidative Stress in a Rat Model of Renal Mass Reduction.  |  Nogueira, A., et al. 2017. Biomed Res Int. 2017: 5125980. PMID: 28326323
  13. Chaetomella acutiseta produces chaetomellic acids A and B which are reversible inhibitors of farnesyl-protein transferase.  |  Lingham, RB., et al. 1993. Appl Microbiol Biotechnol. 40: 370-4. PMID: 7764394
  14. A simple and efficient synthesis of the ras farnesyl-protein transferase inhibitor chaetomellic acid A.  |  Argade, NP. and Naik, RH. 1996. Bioorg Med Chem. 4: 881-3. PMID: 8818238

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Chaetomellic acid A, 5 mg

sc-221420
5 mg
$48.00

Chaetomellic acid A, 25 mg

sc-221420A
25 mg
$255.00